| pubmed-article:11741984 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11741984 | lifeskim:mentions | umls-concept:C0029219 | lld:lifeskim |
| pubmed-article:11741984 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11741984 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:11741984 | lifeskim:mentions | umls-concept:C0207427 | lld:lifeskim |
| pubmed-article:11741984 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:11741984 | lifeskim:mentions | umls-concept:C1415645 | lld:lifeskim |
| pubmed-article:11741984 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:11741984 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:11741984 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11741984 | pubmed:dateCreated | 2002-2-18 | lld:pubmed |
| pubmed-article:11741984 | pubmed:abstractText | Heterogeneous nuclear ribonucleoprotein K (hnRNP K) protein interacts with a subset of cellular RNAs. We used K protein as a bait in the yeast three-hybrid screen to identify RNAs that bind K protein in vivo. A large number of K protein-binding RNA clones were identified from a human hybrid RNA library. These sequences consisted of C-rich patches and were G-poor. Unexpectedly, several of the RNA clones were encoded by the mitochondrial genome. In a subsequent three-hybrid screen of a hybrid RNA library generated from a mouse liver mitochondrial genome, K protein bound RNA sequences encoded by different loci spanning nearly the entire mitochondrial genome. Western blot analysis of extracts from mitochondria and mitochondrial fractions showed that K protein is localized within mitoplasts. Reverse transcriptase PCR of RNA co-immunoprecipitated with K protein from lysates of isolated mitochondria showed that K protein is associated with several processed mitochondrial transcripts. In contrast, in the same assay, the polycistronic nascent mtRNA bound K protein weakly or not at all. Results of this study suggest that K protein acts within functional modules that are responsible for expression of genes in mitochondria. | lld:pubmed |
| pubmed-article:11741984 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11741984 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741984 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11741984 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11741984 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11741984 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11741984 | pubmed:author | pubmed-author:BomsztykKarol... | lld:pubmed |
| pubmed-article:11741984 | pubmed:author | pubmed-author:RychlewskiLes... | lld:pubmed |
| pubmed-article:11741984 | pubmed:author | pubmed-author:OstrowskiJerz... | lld:pubmed |
| pubmed-article:11741984 | pubmed:author | pubmed-author:WyrwiczLucjan... | lld:pubmed |
| pubmed-article:11741984 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11741984 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:11741984 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11741984 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11741984 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11741984 | pubmed:pagination | 6303-10 | lld:pubmed |
| pubmed-article:11741984 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11741984 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11741984 | pubmed:articleTitle | Heterogeneous nuclear ribonucleoprotein K protein associates with multiple mitochondrial transcripts within the organelle. | lld:pubmed |
| pubmed-article:11741984 | pubmed:affiliation | Department of Gastroenterology, Medical Center for Postgraduate Education, Maria Sklodowska-Curie Memorial Cancer Center, and the Institute of Oncology, 02-781 Warsaw, Poland. jostrow@warman.com.pl | lld:pubmed |
| pubmed-article:11741984 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11741984 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11741984 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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