| pubmed-article:11741947 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11741947 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:11741947 | lifeskim:mentions | umls-concept:C0007776 | lld:lifeskim |
| pubmed-article:11741947 | lifeskim:mentions | umls-concept:C0022655 | lld:lifeskim |
| pubmed-article:11741947 | lifeskim:mentions | umls-concept:C0001613 | lld:lifeskim |
| pubmed-article:11741947 | lifeskim:mentions | umls-concept:C0279023 | lld:lifeskim |
| pubmed-article:11741947 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11741947 | pubmed:dateCreated | 2002-2-18 | lld:pubmed |
| pubmed-article:11741947 | pubmed:abstractText | Brain-derived neurotrophic factor (BDNF) has been reported to exert an acute potentiation of synaptic activity. Here we examined the action of BDNF on synchronous spontaneous Ca(2+) oscillations in cultured cerebral cortical neurons prepared from postnatal 2-3-day-old rats. The synchronous spontaneous Ca(2+) oscillations began at approximately DIV 5. It was revealed that voltage-dependent Ca(2+) channels and ionotropic glutamate receptors were involved in the synchronous spontaneous oscillatory activity. BDNF potentiated the frequency of these oscillations. The BDNF-potentiated activity reached 207 +/- 20.1% of basal oscillatory activity. NT-3 and NT-4/5 also induced the potentiation. However, nerve growth factor did not. We examined the correlation between BDNF-induced glutamate release and the BDNF-potentiated oscillatory activity. Both up-regulation of phospholipase C-gamma (PLC-gamma) expression and the BDNF-induced glutamate release occurred at approximately DIV 5 when the BDNF-potentiated oscillations appeared. We confirmed that the BDNF-induced glutamate release occurred through a glutamate transporter that was dependent on the PLC-gamma/IP(3)/Ca(2+) pathway. Transporter inhibitors blocked the BDNF-potentiated oscillations, demonstrating that BDNF enhanced the glutamatergic transmissions in the developing cortical network by inducing glutamate release via a glutamate transporter. | lld:pubmed |
| pubmed-article:11741947 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11741947 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741947 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11741947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11741947 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11741947 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11741947 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11741947 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11741947 | pubmed:author | pubmed-author:NumakawaTadah... | lld:pubmed |
| pubmed-article:11741947 | pubmed:author | pubmed-author:YamagishiSato... | lld:pubmed |
| pubmed-article:11741947 | pubmed:author | pubmed-author:AdachiNaokiN | lld:pubmed |
| pubmed-article:11741947 | pubmed:author | pubmed-author:MatsumotoTomo... | lld:pubmed |
| pubmed-article:11741947 | pubmed:author | pubmed-author:YokomakuDaisa... | lld:pubmed |
| pubmed-article:11741947 | pubmed:author | pubmed-author:YamadaMasashi... | lld:pubmed |
| pubmed-article:11741947 | pubmed:author | pubmed-author:HatanakaHiros... | lld:pubmed |
| pubmed-article:11741947 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11741947 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:11741947 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11741947 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11741947 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11741947 | pubmed:pagination | 6520-9 | lld:pubmed |
| pubmed-article:11741947 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11741947 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11741947 | pubmed:articleTitle | Brain-derived neurotrophic factor-induced potentiation of Ca(2+) oscillations in developing cortical neurons. | lld:pubmed |
| pubmed-article:11741947 | pubmed:affiliation | Division of Protein Biosynthesis, Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan. numakawa@protein.osaka-u.ac.jp | lld:pubmed |
| pubmed-article:11741947 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11741947 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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