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rdf:type |
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lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0003316,
umls-concept:C0205147,
umls-concept:C0205263,
umls-concept:C0220847,
umls-concept:C0439599,
umls-concept:C0439828,
umls-concept:C0439851,
umls-concept:C1444662,
umls-concept:C1552596,
umls-concept:C1947931
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pubmed:issue |
6
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pubmed:dateCreated |
2001-12-19
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pubmed:abstractText |
Hepatitis C virus (HCV) is a major cause worldwide of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma, and the development of an effective vaccine represents a high priority goal. The hyper variable region 1 (HVR1) of the second envelope protein (E2) of HCV contains a principal neutralizing determinant, but it is highly variable among different isolates and it is involved in the escape from host immune response. To be effective, a vaccine should elicit a cross-reacting humoral response against the majority of viral variants. We show that it is possible to achieve a broadly cross-reactive immune response in rabbits by immunization with mimotopes of the HVR1, selected from a specialized phage library using HCV patients' sera. Some of the cross-reacting anti-mimotope antibodies elicited in rabbits, recognize discontinuous epitopes in a manner similar to those induced by the virus in infected patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0161-5890
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pubmed:author |
pubmed-author:CorteseRR,
pubmed-author:ErcoleB BBB,
pubmed-author:FolgoriAA,
pubmed-author:GalfreGG,
pubmed-author:LahmAA,
pubmed-author:MeolaAA,
pubmed-author:MondelliM UMU,
pubmed-author:NicosiaAA,
pubmed-author:PessiAA,
pubmed-author:PezzaneraMM,
pubmed-author:PuntorieroGG,
pubmed-author:RoccaseccaRR,
pubmed-author:TafiRR,
pubmed-author:TramontanoAA,
pubmed-author:ZucchelliSS
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
485-92
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pubmed:dateRevised |
2005-12-23
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pubmed:meshHeading |
pubmed-meshheading:11741698-Amino Acid Sequence,
pubmed-meshheading:11741698-Amino Acid Substitution,
pubmed-meshheading:11741698-Animals,
pubmed-meshheading:11741698-Antibody Specificity,
pubmed-meshheading:11741698-Cross Reactions,
pubmed-meshheading:11741698-Female,
pubmed-meshheading:11741698-Hepatitis C, Chronic,
pubmed-meshheading:11741698-Hepatitis C Antibodies,
pubmed-meshheading:11741698-Humans,
pubmed-meshheading:11741698-Immunodominant Epitopes,
pubmed-meshheading:11741698-Molecular Sequence Data,
pubmed-meshheading:11741698-Peptide Library,
pubmed-meshheading:11741698-Rabbits,
pubmed-meshheading:11741698-Viral Envelope Proteins,
pubmed-meshheading:11741698-Viral Hepatitis Vaccines
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pubmed:year |
2001
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pubmed:articleTitle |
Mimotopes of the hyper variable region 1 of the hepatitis C virus induce cross-reactive antibodies directed against discontinuous epitopes.
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pubmed:affiliation |
Istituto di Ricerche di Biologia Molecolare "P. Angeletti", Via Pontina Km 30.600, 00040 Pomezia, Rome, Italy.
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pubmed:publicationType |
Journal Article
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