Source:http://linkedlifedata.com/resource/pubmed/id/11741161
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2001-12-13
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pubmed:abstractText |
HIV-1-infected men on suppressive highly active antiretroviral therapy (HAART) have a reduction of viral replication in vivo, but HIV-1 RNA is still detectable by certain ultrasensitive reverse transcriptase-PCR assays in blood plasma. Replication-competent virus can also be isolated from both peripheral blood mononuclear cells (PBMC) and seminal cells of these patients. Despite HAART, on-going in vivo infection of HIV-1-seropositive patients' PBMC was demonstrated by the detection of episomal HIV-1 moieties, known as HIV-1 two-long terminal repeat (2-LTR) DNA circles.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0269-9370
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-45
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11741161-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:11741161-DNA, Viral,
pubmed-meshheading:11741161-HIV Infections,
pubmed-meshheading:11741161-HIV Long Terminal Repeat,
pubmed-meshheading:11741161-HIV-1,
pubmed-meshheading:11741161-Humans,
pubmed-meshheading:11741161-Leukocytes, Mononuclear,
pubmed-meshheading:11741161-Male,
pubmed-meshheading:11741161-Polymerase Chain Reaction,
pubmed-meshheading:11741161-RNA, Viral,
pubmed-meshheading:11741161-Semen,
pubmed-meshheading:11741161-Virus Latency
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pubmed:year |
2002
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pubmed:articleTitle |
Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: latency without on-going cellular infections.
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pubmed:affiliation |
Dorrance H. Hamilton Laboratories, Center for Human Virology, Division of Infectious Diseases, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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