Source:http://linkedlifedata.com/resource/pubmed/id/11740730
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2001-12-12
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pubmed:abstractText |
The contribution of individual Fcgamma receptor (FcgammaR) subclasses to meningococcal phagocytosis was studied. In addition, functional FcgammaR polymorphisms were determined in 50 patients with meningococcal disease (MD), in 183 first-degree relatives of MD patients, and in 239 healthy control subjects, to study the association of FcgammaR genotypes with disease. Efficient internalization of opsonized Neisseria meningitidis serogroup B was mediated via multiple FcgammaR subclasses on phagocytes. Accordingly, a low-efficiency combination of FcgammaRIIa-R/R131, FcgammaRIIIa-F/F158, and FcgammaRIIIb-NA2/2 genotypes was increased significantly in relatives of patients with MD, compared with healthy control subjects (P<.05; odds ratio, 2.6; 95% confidence interval, 1.1-6.3). FcgammaRIIa and FcgammaRIIIa genotype distributions differed between patients with sepsis and those with meningitis. Combined genotypes of FcgammaRIIa and interleukin-10 -1082, which was previously reported as being associated with MD outcome, were distributed randomly in control subjects but not in relatives of patients with MD (P<.01). These data provide further evidence for the association of polymorphic genes on chromosome 1 and MD.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
184
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1548-55
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11740730-Adolescent,
pubmed-meshheading:11740730-Adult,
pubmed-meshheading:11740730-Child,
pubmed-meshheading:11740730-Chromosome Mapping,
pubmed-meshheading:11740730-Chromosomes, Human, Pair 1,
pubmed-meshheading:11740730-Genotype,
pubmed-meshheading:11740730-Granulocytes,
pubmed-meshheading:11740730-Humans,
pubmed-meshheading:11740730-Interleukin-10,
pubmed-meshheading:11740730-Meningococcal Infections,
pubmed-meshheading:11740730-Neisseria meningitidis,
pubmed-meshheading:11740730-Neutrophils,
pubmed-meshheading:11740730-Phagocytosis,
pubmed-meshheading:11740730-Polymorphism, Genetic,
pubmed-meshheading:11740730-Receptors, IgG
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pubmed:year |
2001
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pubmed:articleTitle |
Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal disease.
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pubmed:affiliation |
University Medical Center, Dept. of Immunology, Laboratory for Immunotherapy, 3584 EA Utrecht, The Netherlands. L.vdPol@lab.azu.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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