Linked Life Data

11739485

Source:http://linkedlifedata.com/resource/pubmed/id/11739485

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pubmed-article:11739485pubmed:abstractTextThe involvement of OX40 (CD134) in the activation of CD8(+) intestinal intraepithelial lymphocytes (IELs) has been studied using freshly isolated IELs and in vitro CD3-stimulated IELs. Although freshly isolated CD8(+) IELs exhibited properties of activated T cells (CD69 expression and ex vivo cytotoxicity), virtually all CD8(+) IELs from normal mice were devoid of other activation-associated properties, including a lack of expression of OX40 and the ligand for OX40 (OX40L) and an absence of intracellular IFN-gamma staining. However, OX40 and OX40L expression were rapidly up-regulated on CD8 IELs following CD3 stimulation, indicating that both markers on IELs reflect activation-dependent events. Unlike IELs, activated lymph node T cells did not express OX40L, thus indicating that OX40-OX40L communication in the intestinal epithelium is part of a novel CD8 network. Functionally, OX40 expression was exclusively associated with IELs with active intracellular IFN-gamma synthesis and markedly enhanced cell-mediated cytotoxicity. However, OX40 costimulation during CD3-mediated activation significantly suppressed IL-10 synthesis by IELs, whereas blockade of OX40-OX40L by anti-OX40L mAb markedly increased IL-10 production. These findings indicate that: 1) resident CD69(+)OX40(-) IELs constitute a population of partially activated T cells poised for rapid delivery of effector activity, 2) OX40 and OX40L expression defines IELs that have undergone recent immune activation, 3) OX40(+) IELs are significantly more efficient CTL than are OX40(-) IELs, and 4) the local OX40/OX40L system plays a critical role in regulating the magnitude of cytokine responses in the gut epithelium.lld:pubmed
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pubmed-article:11739485pubmed:authorpubmed-author:WangH CHClld:pubmed
pubmed-article:11739485pubmed:authorpubmed-author:KleinJ RJRlld:pubmed
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pubmed-article:11739485pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:11739485pubmed:articleTitleMultiple levels of activation of murine CD8(+) intraepithelial lymphocytes defined by OX40 (CD134) expression: effects on cell-mediated cytotoxicity, IFN-gamma, and IL-10 regulation.lld:pubmed
pubmed-article:11739485pubmed:affiliationDepartment of Basic Sciences, Dental Branch, University of Texas Health Science Center, Houston, TX 77030, USA.lld:pubmed
pubmed-article:11739485pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11739485pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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