Linked Life Data

11739160

Source:http://linkedlifedata.com/resource/pubmed/id/11739160

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2001-12-12
pubmed:abstractText
Red blood cell (RBC) and platelet transfusion requirements in patients given nonmyeloablative versus conventional peripheral blood stem cell (PBSC) transplants from HLA-matched siblings were compared. Between December 1997 and March 2000, 40 patients, aged 21 to 67 years (median 51), with hematologic malignancies underwent nonmyeloablative allografts after either 2 Gy total body irradiation alone (n = 30) or 2 Gy total body irradiation preceded by fludarabine 30 mg/m(2)/d on days -4, -3, and -2 (n = 10). All received postgrafting mycophenolate mofetil and cyclosporine. Controls included 67 concurrent patients, aged 23 to 66 years (median, 46 years), given conventional PBSC transplants following high-dose conditioning and postgrafting methotrexate and cyclosporine. Among patients given nonmyeloablative transplants, 23% required platelet transfusions compared with 100% among patients given conventional grafts (P <.0001). Further, the number of platelet units given to nonmyeloablative recipients was reduced, with a median of 0 (range, 0 to 214) compared with a median of 24 (range, 4 to 358) after conventional transplantation (P <.0001). Sixty-three percent of nonmyeloablative recipients required RBC transfusions compared with 96% of those with conventional grafts (P =.0001). The number of RBC units transfused was also reduced, with a median of 2 (range, 0 to 50) compared with 6 (range, 0 to 34) after conventional transplantation (P =.0001). High transfusion requirements before transplantation and donor-recipient ABO incompatibility increased transfusion requirements in both patient groups, though neither significantly influenced the outcome of the analysis. Neither patient age, splenomegaly at transplantation, development of graft-versus-host disease, nor posttransplantation cytomegalovirus antigenemia or cytomegalovirus disease had statistically significant influences on posttransplantation transfusions.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3584-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11739160-Adult, pubmed-meshheading:11739160-Aged, pubmed-meshheading:11739160-Busulfan, pubmed-meshheading:11739160-Cyclophosphamide, pubmed-meshheading:11739160-Erythrocyte Transfusion, pubmed-meshheading:11739160-Female, pubmed-meshheading:11739160-Hematologic Neoplasms, pubmed-meshheading:11739160-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:11739160-Histocompatibility Testing, pubmed-meshheading:11739160-Humans, pubmed-meshheading:11739160-Immunosuppressive Agents, pubmed-meshheading:11739160-Male, pubmed-meshheading:11739160-Middle Aged, pubmed-meshheading:11739160-Myeloablative Agonists, pubmed-meshheading:11739160-Nuclear Family, pubmed-meshheading:11739160-Platelet Transfusion, pubmed-meshheading:11739160-Transplantation Conditioning, pubmed-meshheading:11739160-Vidarabine, pubmed-meshheading:11739160-Whole-Body Irradiation
pubmed:year
2001
pubmed:articleTitle
Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings.
pubmed:affiliation
Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't