Source:http://linkedlifedata.com/resource/pubmed/id/11739082
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-12-12
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| pubmed:abstractText |
To determine whether increased lipogenesis contributes to human obesity, we measured (postabsorptive state), in lean and obese subjects, lipid synthesis (deuterated water method) and the mRNA concentration (RT-competitive PCR) in subcutaneous adipose tissue of fatty acid synthase (FAS) and sterol regulatory element-binding protein (SREBP)-1c. Before energy restriction, obese subjects had an increased contribution of hepatic lipogenesis to the circulating triglyceride pool (14.5 +/- 1.3 vs. 7.5 +/- 1.9%, P < 0.01) without enhancement of cholesterol synthesis. This increased hepatic lipogenesis represented an excess of 2-5 g/day of triglycerides, which would represent 0.7-1.8 kg on a yearly basis. The lipogenic capacity of adipose tissue appeared, on the contrary, decreased with lower FAS mRNA levels (P < 0.01) and a trend for decreased SREBP-1c mRNA (P = 0.06). Energy restriction in obese patients decreased plasma insulin (P < 0.05) and leptin (P < 0.05) and normalized hepatic lipogenesis. FAS mRNA levels were unchanged, whereas SREBP-1c increased. In conclusion, subjects with established obesity have an increased hepatic lipogenesis that could contribute to their excessive fat mass but no evidence for an increased lipogenic capacity of adipose tissue.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acid Synthetase Complex,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SREBF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sterol Regulatory Element Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0193-1849
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
282
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
E46-51
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11739082-Adipose Tissue,
pubmed-meshheading:11739082-Adult,
pubmed-meshheading:11739082-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:11739082-DNA-Binding Proteins,
pubmed-meshheading:11739082-Fatty Acid Synthetase Complex,
pubmed-meshheading:11739082-Female,
pubmed-meshheading:11739082-Gene Expression,
pubmed-meshheading:11739082-Humans,
pubmed-meshheading:11739082-Lipids,
pubmed-meshheading:11739082-Liver,
pubmed-meshheading:11739082-Male,
pubmed-meshheading:11739082-Middle Aged,
pubmed-meshheading:11739082-Obesity,
pubmed-meshheading:11739082-RNA, Messenger,
pubmed-meshheading:11739082-Reference Values,
pubmed-meshheading:11739082-Sterol Regulatory Element Binding Protein 1,
pubmed-meshheading:11739082-Thinness,
pubmed-meshheading:11739082-Transcription Factors
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| pubmed:year |
2002
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| pubmed:articleTitle |
Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity.
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| pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale Unité 499, Faculté RTH Laennec, 69008 Lyon, France.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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