11738574

Source:http://linkedlifedata.com/resource/pubmed/id/11738574

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0243072, umls-concept:C1257954, umls-concept:C2757001
pubmed:issue	1
pubmed:dateCreated	2001-12-12
pubmed:abstractText	A series of 4-aryl/cycloalkyl-5-phenyloxazole derivatives was synthesized and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1). These compounds were found to be potent and selective COX-2 inhibitors.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents..., http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Oxazoles, http://linkedlifedata.com/resource/pubmed/chemical/PTGS1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0960-894X
pubmed:author	pubmed-author:HarutaJun-ichiJ, pubmed-author:HashimotoHiromasaH, pubmed-author:MaedaKimiyaK, pubmed-author:OzawaKoichiK, pubmed-author:WakitaniKorekiyoK
pubmed:issnType	Print
pubmed:day	7
pubmed:volume	12
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	65-8
pubmed:dateRevised	2005-11-17
pubmed:meshHeading	pubmed-meshheading:11738574-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:11738574-Cyclooxygenase 1, pubmed-meshheading:11738574-Cyclooxygenase 2, pubmed-meshheading:11738574-Cyclooxygenase 2 Inhibitors, pubmed-meshheading:11738574-Cyclooxygenase Inhibitors, pubmed-meshheading:11738574-Drug Design, pubmed-meshheading:11738574-Drug Evaluation, Preclinical, pubmed-meshheading:11738574-Humans, pubmed-meshheading:11738574-Inhibitory Concentration 50, pubmed-meshheading:11738574-Isoenzymes, pubmed-meshheading:11738574-Membrane Proteins, pubmed-meshheading:11738574-Oxazoles, pubmed-meshheading:11738574-Prostaglandin-Endoperoxide Synthases, pubmed-meshheading:11738574-Structure-Activity Relationship
pubmed:year	2002
pubmed:articleTitle	4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors.
pubmed:affiliation	Central Pharmaceutical Research Institute, JT, Inc., 1-1Murasaki-cho, Takatsuki, 569-1125, Osaka, Japan. hiromasa.hashimoto@ims.jti.co.jp
pubmed:publicationType	Journal Article