|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2001-12-12
|
|
pubmed:abstractText |
Protease-activated receptor 2 (PAR-2) is involved in inflammatory, gastrointestinal, and vascular diseases. The aim of the present work was to elucidate the minimal structural features for PAR-2 agonist activity in short peptides. Our study resulted in the discovery of dipeptide derivatives of N(alpha)-benzoyl-Arg(NO(2))-Leu-NH(2) displaying a potency comparable to that of the full-length rat PAR-2 activating peptide (Ser-Leu-Ile-Gly-Arg-Leu-NH(2)).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
12
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
21-4
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:11738565-Animals,
pubmed-meshheading:11738565-Aorta,
pubmed-meshheading:11738565-Arginine,
pubmed-meshheading:11738565-Dipeptides,
pubmed-meshheading:11738565-Drug Design,
pubmed-meshheading:11738565-Drug Evaluation, Preclinical,
pubmed-meshheading:11738565-Leucine,
pubmed-meshheading:11738565-Male,
pubmed-meshheading:11738565-Molecular Structure,
pubmed-meshheading:11738565-Muscle, Smooth, Vascular,
pubmed-meshheading:11738565-Rats,
pubmed-meshheading:11738565-Rats, Wistar,
pubmed-meshheading:11738565-Receptor, PAR-2,
pubmed-meshheading:11738565-Receptors, Thrombin,
pubmed-meshheading:11738565-Structure-Activity Relationship
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Minimal structural requirements for agonist activity of PAR-2 activating peptides.
|
|
pubmed:affiliation |
Department of Pharmaceutical Chemistry, University of Naples 'Federico II', Via D. Montesano 49, 80131, Naples, Italy.
|
|
pubmed:publicationType |
Journal Article
|
