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rdf:type |
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lifeskim:mentions |
umls-concept:C0001128,
umls-concept:C0003209,
umls-concept:C0034251,
umls-concept:C0205314,
umls-concept:C0205464,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0243072,
umls-concept:C0450442,
umls-concept:C0456387,
umls-concept:C0679622,
umls-concept:C1515999,
umls-concept:C1707689,
umls-concept:C1883254
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pubmed:issue |
1
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pubmed:dateCreated |
2001-12-12
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pubmed:abstractText |
A series of pyrazolo[3,4-b]thieno[2,3-d]pyridine alkanoic acid derivatives has been synthesized and evaluated as thromboxane synthetase inhibitors and leukotriene D(4) receptor antagonists. The glutaric acid derivative LASSBio341 (6) was shown to be active in arachidonic acid-induced platelet aggregation (IC(50)=0.14 microM) and inhibition of the contraction of guinea pig tracheal strip induced with LTD(4) (IC(50) = 43.7 microM), displaying still in vivo anti-inflammatory profile.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Leukotriene Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Aggregation Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leukotriene,
http://linkedlifedata.com/resource/pubmed/chemical/Thiophenes,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane-A Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/cysteinyl leukotriene receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/leukotriene D4 receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11738562-Animals,
pubmed-meshheading:11738562-Anti-Inflammatory Agents,
pubmed-meshheading:11738562-Disease Models, Animal,
pubmed-meshheading:11738562-Drug Design,
pubmed-meshheading:11738562-Drug Evaluation, Preclinical,
pubmed-meshheading:11738562-Edema,
pubmed-meshheading:11738562-Leukotriene Antagonists,
pubmed-meshheading:11738562-Membrane Proteins,
pubmed-meshheading:11738562-Platelet Aggregation,
pubmed-meshheading:11738562-Platelet Aggregation Inhibitors,
pubmed-meshheading:11738562-Pleurisy,
pubmed-meshheading:11738562-Pyrazoles,
pubmed-meshheading:11738562-Pyridines,
pubmed-meshheading:11738562-Rabbits,
pubmed-meshheading:11738562-Rats,
pubmed-meshheading:11738562-Receptors, Leukotriene,
pubmed-meshheading:11738562-Structure-Activity Relationship,
pubmed-meshheading:11738562-Thiophenes,
pubmed-meshheading:11738562-Thromboxane-A Synthase
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pubmed:year |
2002
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pubmed:articleTitle |
Design, synthesis and pharmacological evaluation of novel pyrazolo[3,4-b]thieno[2,3-d]pyridine acid derivatives: a new class of anti-inflammatory and anti-platelet agents.
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pubmed:affiliation |
Instituto de Química, Universidade Federal do Rio de Janeiro, 21949-900, RJ, Rio de Janeiro, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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