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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-12-12
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pubmed:abstractText |
Individual risk of thrombotic disease is highly associated with allelic sequence variations in the blood clotting factor V (F5) and factor II (F2) genes. The polymorphism (G1691A) in F5 causing the amino acid substitution R506Q and a genetic variation in the 3' untranslated region of F2 (G20210A) are highly prevalent in the Caucasian population. These findings raise the need for an efficient, cost-effective screening technique.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0009-9120
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
531-6
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11738388-Alleles,
pubmed-meshheading:11738388-Base Sequence,
pubmed-meshheading:11738388-Factor V,
pubmed-meshheading:11738388-Female,
pubmed-meshheading:11738388-Genetic Predisposition to Disease,
pubmed-meshheading:11738388-Genetic Testing,
pubmed-meshheading:11738388-Genetic Variation,
pubmed-meshheading:11738388-Genotype,
pubmed-meshheading:11738388-Humans,
pubmed-meshheading:11738388-Molecular Sequence Data,
pubmed-meshheading:11738388-Prothrombin,
pubmed-meshheading:11738388-Risk Factors,
pubmed-meshheading:11738388-Sequence Analysis, DNA,
pubmed-meshheading:11738388-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:11738388-Thrombosis
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pubmed:year |
2001
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pubmed:articleTitle |
Genotyping of thrombotic risk factors by MALDI-TOF mass spectrometry.
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pubmed:affiliation |
Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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