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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-12-13
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pubmed:abstractText |
In order to explore whether monophosphoryl lipid A (MLA)-induced delayed cadioprotection is mediated by calcitonin gene-related peptide (CGRP) and the regulatory effect of inducible heme oxygenase isorform (HO-1)/carbon monoxide (CO) on CGRP synthesis and release, the expression of CGRP and HO-1 in dorsal root ganglia (DRG) and CGRP concentration in plasma were determined in rats. Pretreatment with MLA (500 microg/kg, i.p.) significantly reduced infarct size and creatine kinase release after the 45-min coronary artery occlusion and 180-min reperfusion. MLA caused a significant increase in the expression of CGRP and HO-1 and plasma concentrations of CGRP. The cardioprotection as well as the synthesis and release of CGRP induced by MLA were completely abolished by pretreatment with zinc protoporphrin IX (ZnPP-9), an inhibitor of HO-1, or by capsaicin (50 mg/kg, s.c.), which selectively depletes transmitters in capsaicin-sensitive sensory nerves. Pretreatment with Znpp-9 had no effect on HO-1 expression, but capsaicin abrogated the expression of HO-1 induced by MLA in DRG. These results suggest that the delayed cardioprotection afforded by MLA is mediated by CGRP via activation of the HO-1 pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Calcitonin Gene-Related Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Monoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Cardiotonic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Creatine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase (Decyclizing),
http://linkedlifedata.com/resource/pubmed/chemical/Heme Oxygenase-1,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid A,
http://linkedlifedata.com/resource/pubmed/chemical/Protoporphyrins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/monophosphoryl lipid A,
http://linkedlifedata.com/resource/pubmed/chemical/zinc protoporphyrin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0167-0115
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11738242-Adjuvants, Immunologic,
pubmed-meshheading:11738242-Animals,
pubmed-meshheading:11738242-Calcitonin Gene-Related Peptide,
pubmed-meshheading:11738242-Capsaicin,
pubmed-meshheading:11738242-Carbon Monoxide,
pubmed-meshheading:11738242-Cardiotonic Agents,
pubmed-meshheading:11738242-Creatine Kinase,
pubmed-meshheading:11738242-Ganglia, Spinal,
pubmed-meshheading:11738242-Heme Oxygenase (Decyclizing),
pubmed-meshheading:11738242-Heme Oxygenase-1,
pubmed-meshheading:11738242-Injections, Intraperitoneal,
pubmed-meshheading:11738242-Ischemic Preconditioning, Myocardial,
pubmed-meshheading:11738242-Lipid A,
pubmed-meshheading:11738242-Male,
pubmed-meshheading:11738242-Myocardial Infarction,
pubmed-meshheading:11738242-Myocardium,
pubmed-meshheading:11738242-Protoporphyrins,
pubmed-meshheading:11738242-RNA, Messenger,
pubmed-meshheading:11738242-Rats,
pubmed-meshheading:11738242-Rats, Sprague-Dawley,
pubmed-meshheading:11738242-Reperfusion Injury,
pubmed-meshheading:11738242-Signal Transduction,
pubmed-meshheading:11738242-Time Factors
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pubmed:year |
2002
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pubmed:articleTitle |
The heme oxygenase-1 pathway is involved in calcitonin gene-related peptide-mediated delayed cardioprotection induced by monophosphoryl lipid A in rats.
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pubmed:affiliation |
Department of Pharmacology, Xiang-Ya Medical College, Central South University, Hunan 410078, Changsha, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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