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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-12-12
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pubmed:abstractText |
IL-15 is produced by a wide variety of tissues in response to inflammatory stimuli. We examined the effect of IL-15 in supporting the maturation of monocytes to dendritic cells in ex vivo culture. IL-15 transformed CD14(+) monocytes to mature dendritic cells. These dendritic cells were similar to those obtained from monocyte cultures treated with a combination of the cytokines GM-CSF, IL-4 and TNF-alpha. The effects of IL-15 did not depend on endogenously produced GM-CSF. The IL-15-induced dendritic cells also expressed chemokines and stimulated strong allo-responses that were characteristic of mature dendritic cells. These data indicate that CD14(+) monocytes respond to IL-15 by undergoing morphological transformation and acquiring characteristic dendritic cell features that facilitate antigen-specific responses of T cells. Thus, the release of IL-15 by inflammatory stimuli may induce the conversion of monocytes to immuno-stimulatory dendritic cells to support primary immune responses against pathogens.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-10202112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-10358752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-10448137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-10510393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-10591187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-10657604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-10671230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-10704456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-10784451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-10811870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-1279441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-1281554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-1714795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-1875171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-1910679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-7641685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8026467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8145033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8170963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8178155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8530383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8543818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8612127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8618037,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8637918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8639878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8757333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8976174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-8992997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9039784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9045914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9058793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9091583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9294138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9396779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9521319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9620680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9795392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9846688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11737061-9949171
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD14,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD86,
http://linkedlifedata.com/resource/pubmed/chemical/CD86 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte-Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
447-55
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11737061-Antigens, CD,
pubmed-meshheading:11737061-Antigens, CD14,
pubmed-meshheading:11737061-Antigens, CD86,
pubmed-meshheading:11737061-Cell Differentiation,
pubmed-meshheading:11737061-Chemokines,
pubmed-meshheading:11737061-Dendritic Cells,
pubmed-meshheading:11737061-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:11737061-HLA-DR Antigens,
pubmed-meshheading:11737061-Humans,
pubmed-meshheading:11737061-Interleukin-15,
pubmed-meshheading:11737061-Interleukin-4,
pubmed-meshheading:11737061-Lymphocyte Activation,
pubmed-meshheading:11737061-Membrane Glycoproteins,
pubmed-meshheading:11737061-Monocytes,
pubmed-meshheading:11737061-T-Lymphocytes,
pubmed-meshheading:11737061-Tumor Necrosis Factor-alpha
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pubmed:year |
2001
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pubmed:articleTitle |
IL-15-induced conversion of monocytes to mature dendritic cells.
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pubmed:affiliation |
Laboratory of Molecular Immunology, Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA. Kamal.Saikh@det.amedd.army.mil
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pubmed:publicationType |
Journal Article,
In Vitro
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