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rdf:type |
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lifeskim:mentions |
umls-concept:C0003360,
umls-concept:C0006104,
umls-concept:C0008281,
umls-concept:C0009491,
umls-concept:C0019588,
umls-concept:C0032743,
umls-concept:C0058895,
umls-concept:C0086418,
umls-concept:C0679575,
umls-concept:C1579762,
umls-concept:C1955826,
umls-concept:C2827063
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pubmed:issue |
5
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pubmed:dateCreated |
2001-12-12
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pubmed:abstractText |
Sedation induced by antihistamines is widely recognized to be caused by their penetration through the blood-brain-barrier and the consequent occupation of brain histamine H1-receptors. We previously studied the mechanism of sedation caused by antihistamines using positron emission tomography (PET). Recently, we revealed the nonsedative characteristic of ebastine, a second-generation antihistamine, with cognitive performance tests. In the present study, H1-receptor occupation by ebastine was examined in the human brain using PET.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-10368923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-10444209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-10597869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-10694210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-10974435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-1584454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-1684273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-1722337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-2384545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-2905150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-3141597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-3559970,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-448359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-6129863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-7907873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-7909915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-7912071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-8096817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-8335064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-8564232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-8917588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11736858-9460522
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0306-5251
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pubmed:author |
pubmed-author:AraiHH,
pubmed-author:FujiiTT,
pubmed-author:HiguchiMM,
pubmed-author:IdeJJ,
pubmed-author:ItohMM,
pubmed-author:IwataRR,
pubmed-author:KanoMM,
pubmed-author:KomemushiSS,
pubmed-author:MatsudaMM,
pubmed-author:MizukiYY,
pubmed-author:OkamuraNN,
pubmed-author:SasakiHH,
pubmed-author:TagawaMM,
pubmed-author:WatanabeTT,
pubmed-author:YanaiKK
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
501-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11736858-Adult,
pubmed-meshheading:11736858-Butyrophenones,
pubmed-meshheading:11736858-Carbon Radioisotopes,
pubmed-meshheading:11736858-Cerebral Cortex,
pubmed-meshheading:11736858-Chlorpheniramine,
pubmed-meshheading:11736858-Cross-Over Studies,
pubmed-meshheading:11736858-Histamine H1 Antagonists,
pubmed-meshheading:11736858-Humans,
pubmed-meshheading:11736858-Male,
pubmed-meshheading:11736858-Models, Biological,
pubmed-meshheading:11736858-Piperidines,
pubmed-meshheading:11736858-Receptors, Histamine H1,
pubmed-meshheading:11736858-Single-Blind Method,
pubmed-meshheading:11736858-Thalamus,
pubmed-meshheading:11736858-Tomography, Emission-Computed,
pubmed-meshheading:11736858-Treatment Outcome
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pubmed:year |
2001
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pubmed:articleTitle |
Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine.
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pubmed:affiliation |
Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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