rdf:type |
|
lifeskim:mentions |
umls-concept:C0023884,
umls-concept:C0031676,
umls-concept:C0032105,
umls-concept:C0034085,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205178,
umls-concept:C0242184,
umls-concept:C0243126,
umls-concept:C0851287,
umls-concept:C1280500
|
pubmed:issue |
1
|
pubmed:dateCreated |
1975-9-22
|
pubmed:abstractText |
Exposure of adult rats to hypobaric hypoxia caused hypolipidemia, hypotriglyceridemia and hypophospholipidemia. Hypobaric hypoxia produced an increase in liver triglyceride and cholesterol levels and a decrease in lung triglyceride, total phospholipid and phosphatidyl choline. The proportion of phosphatidyl choline in the pulmonary surfactant fraction I phospholipids (responsible for reducing surface tension) decreased (55.2% as compared to 80.4% in control animals). Incorporation of 32-P into liver phosphatidyl ethanolamine was significantly increased, incorporation into lung phosphatidyl choline and phosphatidyl ethanolamine was increased whereas a decreased incorporation into plasma phosphatidyl choline was observed. The data suggest an enhanced lipid synthesis in liver with a probable impairment of mobilization into plasma.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0300-5429
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
5
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
27-36
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1173571-Animals,
pubmed-meshheading:1173571-Anoxia,
pubmed-meshheading:1173571-Cholesterol,
pubmed-meshheading:1173571-Liver,
pubmed-meshheading:1173571-Lung,
pubmed-meshheading:1173571-Male,
pubmed-meshheading:1173571-Phosphatidylcholines,
pubmed-meshheading:1173571-Phosphatidylethanolamines,
pubmed-meshheading:1173571-Phospholipids,
pubmed-meshheading:1173571-Phosphorus Radioisotopes,
pubmed-meshheading:1173571-Pulmonary Alveoli,
pubmed-meshheading:1173571-Pulmonary Surfactants,
pubmed-meshheading:1173571-Rats,
pubmed-meshheading:1173571-Triglycerides
|
pubmed:year |
1975
|
pubmed:articleTitle |
Effect of acute hypobaric hypoxia on 32-P incorporation into phospholipids of alveolar surfactant, lung, liver and plasma of rat.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
|