Linked Life Data

11735096

Source:http://linkedlifedata.com/resource/pubmed/id/11735096

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2001-12-5
pubmed:abstractText
Relationships have been demonstrated between insulin sensitivity and the fatty acid (FA) composition of serum and tissue lipids in adult humans. The present study aimed to investigate the above relationships in different groups of type 2 diabetic patients (DM2). The FA composition of serum phospholipids (S-PL) measured by gas liquid chromatography and insulin action during a 2-step hyperinsulinemic isoglycemic clamp (1 and 10 mU/kg. min) were determined in 21 newly diagnosed DM2 subjects (DMN), in groups of long-term DM2 patients treated with hypoglycemic agents (DMH; n = 21) or diet alone (DMD; n = 11), and in 24 healthy subjects (HS). In diabetics, the metabolic clearance rates of glucose at both insulin levels (MCR(glu)submax and MCR(glu)max) were significantly reduced compared with HS (MCR(glu)submax DMN, 5.35 +/- 2.7 mL x kg(-1) x min(-1), DMH, 5.38 +/- 2.17 mL x kg(-1) x min(-1); DMD, 5.48 +/- 2.35 mL x kg(-1) x min(-1) v HS, 10.9 +/- 3.3 mL x kg(-1) x min(-1); P <.01; MCR(glu)max DMN, 13.3 +/- 3.3 mL x kg(-1) x min(-1); DMH, 12.5 +/- 3.0 mL x kg(-1) x min(-1); DMD, 13.3 +/- 3.0 mL x kg(-1) x min(-1) v HS, 17.4 +/- 3.8 mL x kg(-1) x min(-1); P <.05). Increased contents of highly unsaturated n-6 family FA (P <.01), arachidonic acid in particular (DMN, 10.98% +/- 1.79%; DMD, 10.78% +/- 1.64%; DMH, 10.97% +/- 1.7% v HS, 8.51% +/- 1.53%; P <.001), were found in all groups of diabetics compared with HS, while lower levels of linoleic acid were seen in DMN (P <.001) and DMH (P <.05). The contents of saturated FA and monounsaturated FA were comparable in HS, DMN, and DMD. While in HS there were significant negative correlations between MCR(glu) and the contents of saturated FA and a positive association between insulin action and proportions of linoleic and arachidonic acids, no significant relationships were found in diabetic subjects. Different groups of DM2 patients show an altered FA pattern of S-PL, which is not related to insulin action. The above data support the hypothesis that changes in FA composition may play a role in modulating insulin action in peripheral tissues, but cannot explain the insulin resistance (IR) in DM2 patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0026-0495
pubmed:author
pubmed:copyrightInfo
Copyright 2001 by W.B. Saunders Company
pubmed:issnType
Print
pubmed:volume
50
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1472-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:11735096-Adult, pubmed-meshheading:11735096-Arachidonic Acid, pubmed-meshheading:11735096-Blood Glucose, pubmed-meshheading:11735096-C-Peptide, pubmed-meshheading:11735096-Diabetes Mellitus, Type 2, pubmed-meshheading:11735096-Fatty Acids, pubmed-meshheading:11735096-Fatty Acids, Omega-3, pubmed-meshheading:11735096-Fatty Acids, Omega-6, pubmed-meshheading:11735096-Fatty Acids, Unsaturated, pubmed-meshheading:11735096-Glucose Clamp Technique, pubmed-meshheading:11735096-Hemoglobin A, Glycosylated, pubmed-meshheading:11735096-Humans, pubmed-meshheading:11735096-Insulin, pubmed-meshheading:11735096-Insulin Resistance, pubmed-meshheading:11735096-Kinetics, pubmed-meshheading:11735096-Linoleic Acid, pubmed-meshheading:11735096-Male, pubmed-meshheading:11735096-Metabolic Clearance Rate, pubmed-meshheading:11735096-Middle Aged, pubmed-meshheading:11735096-Phospholipids
pubmed:year
2001
pubmed:articleTitle
Serum phospholipid fatty acid composition and insulin action in type 2 diabetic patients.
pubmed:affiliation
Diabetes Center of the Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't