Source:http://linkedlifedata.com/resource/pubmed/id/11734915
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
2001-12-5
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pubmed:abstractText |
The aim of this study was to evaluate the usefulness of technetium-99m sestamibi scintimammography (SSM) and combined use of SSM and X-ray mammography (MG) in premenopausal patients with small (< or =2 cm) suspicious breast lesions. Eighty-seven premenopausal women (median age 47 years, range 32-52) with breast lesions ranging from 4 to 20 mm in greatest diameter (median 12 mm) and detected by MG, underwent SSM prior to open breast biopsy. A planar camera and single-photon emission tomography (SPET) technique were used in 23 (26.4%) and 64 (73.6%) patients, respectively. At histological examination, 72 (82.8%) breast cancers (pT1a=3, pT1b=27, pT1c=42) and 15 (17.2%) benign masses were found. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MG and SSM were 80.6% vs 80.6%, 60.0% vs 93.3% (P<0.05), 90.6% vs 98.3%, 39.1% vs 50.0% and 77.0% vs 82.8%, respectively. MG + SSM together had a sensitivity of 94.4% (P<0.05 vs SSM alone) and an accuracy of 82.8% for the detection of breast cancer. Tumours undetected by both MG and SSM were significantly (P<0.05) smaller than those correctly diagnosed. Patients with false-negative MG were younger (P<0.05) than those with tumours correctly detected, while SSM sensitivity was independent (P=NS) of age. In conclusion, in premenopausal patients with small breast lesions, the sensitivity of SSM and MG is similar (P=NS), whereas the specificity of SSM is significantly higher (P<0.05) than that of MG. Furthermore, the combination of MG and SSM offers significantly improved sensitivity and accuracy in comparison with the individual techniques, suggesting a complementary role of SSM in the detection of breast cancer in younger patients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0340-6997
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1776-80
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11734915-Breast,
pubmed-meshheading:11734915-Breast Neoplasms,
pubmed-meshheading:11734915-Female,
pubmed-meshheading:11734915-Humans,
pubmed-meshheading:11734915-Mammography,
pubmed-meshheading:11734915-Middle Aged,
pubmed-meshheading:11734915-Predictive Value of Tests,
pubmed-meshheading:11734915-Premenopause,
pubmed-meshheading:11734915-Radiopharmaceuticals,
pubmed-meshheading:11734915-Sensitivity and Specificity,
pubmed-meshheading:11734915-Technetium Tc 99m Sestamibi,
pubmed-meshheading:11734915-Tomography, Emission-Computed, Single-Photon
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pubmed:year |
2001
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pubmed:articleTitle |
Accuracy of technetium-99m sestamibi scintimammography and X-ray mammography in premenopausal women with suspected breast cancer.
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pubmed:affiliation |
Endocrine Surgery Unit, Department of Surgical and Gastroenterological Sciences, University of Padua Medical School, via Giustiniani 2, 35128 Padua, Italy. flumachi@unipd.it
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pubmed:publicationType |
Journal Article
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