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rdf:type |
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lifeskim:mentions |
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0036525,
umls-concept:C0040690,
umls-concept:C0205281,
umls-concept:C0431085,
umls-concept:C1458155,
umls-concept:C1516240,
umls-concept:C1522484,
umls-concept:C1533691,
umls-concept:C1627358,
umls-concept:C2349975
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pubmed:issue |
1
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pubmed:dateCreated |
2001-12-5
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pubmed:abstractText |
We investigated the effects of transforming growth factor-beta (TGF-beta) on biological behavior of a weakly malignant rat mammary carcinoma ER-1 cell line. TGF-beta enhanced the tumorigenic and metastatic capacity of ER-1 cells and their in vitro invasiveness to rat mesothelial and endothelial cell. Further cell biological analysis indicated that the increased invasive and metastatic capacity of ER-1 cells by TGF-beta was due to the increase in cell motility and adhesion to the mesothelial and endothelial cell monolayers. Thus, it is suggested that TGF-beta acts on ER-1 cells as a progression-enhancing factor which stimulates their adhesive and motile activities.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/ER1 protein, Xenopus,
http://linkedlifedata.com/resource/pubmed/chemical/Hyaluronic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Hyaluronoglucosaminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Xenopus Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
175
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
95-106
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11734341-Animals,
pubmed-meshheading:11734341-Antibodies,
pubmed-meshheading:11734341-Antigens, CD44,
pubmed-meshheading:11734341-Cell Adhesion,
pubmed-meshheading:11734341-Cell Adhesion Molecules,
pubmed-meshheading:11734341-Cell Movement,
pubmed-meshheading:11734341-Chemotaxis,
pubmed-meshheading:11734341-Dose-Response Relationship, Drug,
pubmed-meshheading:11734341-Female,
pubmed-meshheading:11734341-Hyaluronic Acid,
pubmed-meshheading:11734341-Hyaluronoglucosaminidase,
pubmed-meshheading:11734341-Immediate-Early Proteins,
pubmed-meshheading:11734341-Kinetics,
pubmed-meshheading:11734341-Mammary Neoplasms, Experimental,
pubmed-meshheading:11734341-Mice,
pubmed-meshheading:11734341-Neoplasm Invasiveness,
pubmed-meshheading:11734341-Neoplasm Metastasis,
pubmed-meshheading:11734341-Nuclear Proteins,
pubmed-meshheading:11734341-Trans-Activators,
pubmed-meshheading:11734341-Transforming Growth Factor beta,
pubmed-meshheading:11734341-Xenopus Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
Enhancement of tumorigenic, metastatic and in vitro invasive capacity of rat mammary tumor cells by transforming growth factor-beta.
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pubmed:affiliation |
Division of Cancer-Related Genes, Institute for Genetic Medicine, Hokkaido University, Kita-15, Nishi-7, Kita-ku, 060-0815, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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