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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-12-5
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pubmed:abstractText |
Long-term survival of chronic myeloid leukaemia (CML) patients transplanted in chronic phase with a replete marrow have been described previously. The same success has not been achieved with patients in more advanced stages of the disease. We describe a CML patient who received an allogeneic bone marrow transplantation in accelerated phase. Cytogenetic and molecular analysis confirmed donor chimaerism, and the absence of the BCR-ABL mRNA. Almost 12 years post-transplant relapse was noted. Cytogenetic analyses showed a complex evolving karyotype. These findings are correlated with the longitudinal molecular analysis utilising real-time and VNTR PCR.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0145-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11734309-Adolescent,
pubmed-meshheading:11734309-Bone Marrow Transplantation,
pubmed-meshheading:11734309-Fatal Outcome,
pubmed-meshheading:11734309-Fusion Proteins, bcr-abl,
pubmed-meshheading:11734309-Graft vs Tumor Effect,
pubmed-meshheading:11734309-Humans,
pubmed-meshheading:11734309-Karyotyping,
pubmed-meshheading:11734309-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:11734309-Male,
pubmed-meshheading:11734309-Neoplasm Recurrence, Local,
pubmed-meshheading:11734309-RNA, Messenger,
pubmed-meshheading:11734309-RNA, Neoplasm,
pubmed-meshheading:11734309-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11734309-Time Factors,
pubmed-meshheading:11734309-Transplantation, Homologous,
pubmed-meshheading:11734309-Transplantation Chimera
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pubmed:year |
2002
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pubmed:articleTitle |
Rapid clonal development in a relapsed CML 11 years post replete allogeneic bone marrow transplantation.
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pubmed:affiliation |
Haematology Department, St Vincent's Hospital Darlinghurst, Darlinghurst, NSW 2010, Sydney, Australia. phil.kearney@activebiotech.com
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pubmed:publicationType |
Journal Article,
Case Reports
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