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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2001-12-4
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pubmed:abstractText |
The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a malignancy of mature B cells with a characteristic clinical presentation but a variable clinical course. The rearranged immunoglobulin (Ig) genes of CLL cells may be either germ-line in sequence or somatically mutated. Lack of Ig mutations defined a distinctly worse prognostic group of CLL patients raising the possibility that CLL comprises two distinct diseases. Using genomic-scale gene expression profiling, we show that CLL is characterized by a common gene expression "signature," irrespective of Ig mutational status, suggesting that CLL cases share a common mechanism of transformation and/or cell of origin. Nonetheless, the expression of hundreds of other genes correlated with the Ig mutational status, including many genes that are modulated in expression during mitogenic B cell receptor signaling. These genes were used to build a CLL subtype predictor that may help in the clinical classification of patients with this disease.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-10469298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-10477712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-10477713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-10611223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-10676951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-10689303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-10921899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-10933391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-10979972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-11069074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-11123281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-11232339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-1956400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-2378986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-2462608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-2473761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-8011288,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-8035606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-8562930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-8617505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-8652811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-8704181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-8977195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-9000000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-9038101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-9602370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-9788964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11733578-9850860
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1007
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pubmed:author |
pubmed-author:AlizadehA AAA,
pubmed-author:BotsteinDD,
pubmed-author:BrownP OPO,
pubmed-author:ByrdJ CJC,
pubmed-author:ChesonB DBD,
pubmed-author:ChiorazziNN,
pubmed-author:DavisR ERE,
pubmed-author:GreverM RMR,
pubmed-author:KippsT JTJ,
pubmed-author:PickeralO KOK,
pubmed-author:PowellJJ,
pubmed-author:RassentiL ZLZ,
pubmed-author:RosenwaldAA,
pubmed-author:SimonRR,
pubmed-author:StaudtL MLM,
pubmed-author:WidhopfGG,
pubmed-author:WilsonW HWH,
pubmed-author:YangLL,
pubmed-author:YuXX
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
194
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1639-47
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2001
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pubmed:articleTitle |
Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia.
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pubmed:affiliation |
Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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