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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2002-2-11
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pubmed:abstractText |
Crystals were discovered within the aged lung and at sites of chronic inflammation in a mouse model of chronic granulomatous disease. Following re-crystallization at neutral pH, the crystals were identified as the chitinase-like protein Ym1, expressed in organs of the lymphoreticular system, the lung, and distal stomach. Ym1 was shown to be a neutrophil granule protein and to have weak beta-N-acetylglucosaminidase activity, indicating that it might contribute to the digestion of glycosaminoglycans. Crystal formation is likely to be a function of excess neutrophil turnover at sites of inflammation in the chronic granulomatous disease mouse. Failure to remove subcutaneous Ym1 crystals injected into knockout mice indicates that a failure of digestion may also contribute to crystallization.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9258
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5468-75
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11733538-Animals,
pubmed-meshheading:11733538-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:11733538-Embryo, Mammalian,
pubmed-meshheading:11733538-Hydrogen-Ion Concentration,
pubmed-meshheading:11733538-Immunohistochemistry,
pubmed-meshheading:11733538-Inflammation,
pubmed-meshheading:11733538-Kinetics,
pubmed-meshheading:11733538-Lectins,
pubmed-meshheading:11733538-Lung,
pubmed-meshheading:11733538-Mice,
pubmed-meshheading:11733538-Mice, Knockout,
pubmed-meshheading:11733538-Models, Genetic,
pubmed-meshheading:11733538-Mutagenesis, Site-Directed,
pubmed-meshheading:11733538-NADPH Oxidase,
pubmed-meshheading:11733538-Neutrophils,
pubmed-meshheading:11733538-Phosphoproteins,
pubmed-meshheading:11733538-Stem Cells,
pubmed-meshheading:11733538-Subcellular Fractions,
pubmed-meshheading:11733538-Time Factors,
pubmed-meshheading:11733538-Tissue Distribution,
pubmed-meshheading:11733538-beta-N-Acetylhexosaminidases
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pubmed:year |
2002
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pubmed:articleTitle |
Ym1 is a neutrophil granule protein that crystallizes in p47phox-deficient mice.
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pubmed:affiliation |
Department of Medicine, University College London, London WC1E 6JJ, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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