Linked Life Data

11733115

Source:http://linkedlifedata.com/resource/pubmed/id/11733115

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-12-4
pubmed:abstractText
Polyhydroxyalkanoates (PHAs) comprise a large class of polyesters that are synthesized by many bacteria as an intracellular carbon and energy compound. Analysis of isolated PHAs reveal interesting properties such as biodegradability and biocompatibility. Research was focused only recently on the application of PHA in implants, scaffolds in tissue engineering, or as drug carriers. Such applications require that PHA be produced at a constant and reproducible quality. To date this can be achieved best through bacterial production in continuous culture where growth conditions are kept constant (chemostat). Recently, it was found that PHA producing bacteria are able to grow simultaneously limited by carbon and nitrogen substrates. Thus, it became possible to produce PHA at high yields on toxic substrate and also control its composition accurately (tailor-made synthesis). Finally, applications of PHA in medicine are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0169-409X
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Occurrence, synthesis and medical application of bacterial polyhydroxyalkanoate.
pubmed:affiliation
Department of Microbiology, Swiss Federal Institute for Environmental Science and Technology (EAWAG), Ueberlandstrasse 133, P.O. Box 611, CH-8600 Dübendorf, Switzerland. manfred.zinn@eawag.ch
pubmed:publicationType
Journal Article, Review