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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 2
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pubmed:dateCreated |
2001-12-3
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pubmed:abstractText |
1. Prolonged exercise results in a progressive decline in glycogen content and a concomitant increase in the release of the cytokine interleukin-6 (IL-6) from contracting muscle. This study tests the hypothesis that the exercise-induced IL-6 release from contracting muscle is linked to the intramuscular glycogen availability. 2. Seven men performed 5 h of a two-legged knee-extensor exercise, with one leg with normal, and one leg with reduced, muscle glycogen content. Muscle biopsies were obtained before (pre-ex), immediately after (end-ex) and 3 h into recovery (3 h rec) from exercise in both legs. In addition, catheters were placed in one femoral artery and both femoral veins and blood was sampled from these catheters prior to exercise and at 1 h intervals during exercise and into recovery. 3. Pre-exercise glycogen content was lower in the glycogen-depleted leg compared with the control leg. Intramuscular IL-6 mRNA levels increased with exercise in both legs, but this increase was augmented in the leg having the lowest glycogen content at end-ex. The arterial plasma concentration of IL-6 increased from 0.6 +/- 0.1 ng x l(-1) pre-ex to 21.7 +/- 5.6 ng x l(-1) end-ex. The depleted leg had already released IL-6 after 1 h (4.38 +/- 2.80 ng x min(-1) (P < 0.05)), whereas no significant release was observed in the control leg (0.36 +/- 0.14 ng x min(-1)). A significant net IL-6 release was not observed until 2 h in the control leg. 4. This study demonstrates that glycogen availability is associated with alterations in the rate of IL-6 production and release in contracting skeletal muscle.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-10362627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-10726919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-10817157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-10893431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-11018114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-11050539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-11060137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-11080244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-11080265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-11080266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-11245592,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-11350773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-11389214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-4066596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-7762632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-7906280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-8447379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-8645290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-8814329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-9134917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-9338449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-9398733,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-9518745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-9581683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-9588607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11731593-9824725
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-3751
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
537
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
633-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11731593-Adult,
pubmed-meshheading:11731593-Biological Availability,
pubmed-meshheading:11731593-Exercise,
pubmed-meshheading:11731593-Glycogen,
pubmed-meshheading:11731593-Humans,
pubmed-meshheading:11731593-Interleukin-6,
pubmed-meshheading:11731593-Knee,
pubmed-meshheading:11731593-Male,
pubmed-meshheading:11731593-Muscle, Skeletal,
pubmed-meshheading:11731593-Muscle Contraction
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pubmed:year |
2001
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pubmed:articleTitle |
Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content.
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pubmed:affiliation |
The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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