Source:http://linkedlifedata.com/resource/pubmed/id/11730829
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2001-12-3
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| pubmed:abstractText |
In order to characterize the lipoprotein abnormalities in familial combined hyperlipidemia (FCHL) and to describe factors associated with the stability of the FCHL phenotype during 20-year follow-up, 287 individuals from 48 families with FCHL originally identified in the early 1970s (baseline) were studied. Hyperlipidemia was defined as lipid-lowering medication use, or > or =age- and sex-specific 90th percentile for triglycerides or cholesterol. Triglyceride, cholesterol and medical history data were obtained at baseline and 20-year follow-up. Additional follow-up measures included HDL-C, LDL-C, LDL particle size, lipoprotein(a), apolipoprotein (apo) A-I, apoB, and apoE polymorphism. Longitudinally, two-thirds of relatives were consistently normolipidemic or hyperlipidemic, and one third were discordant for hyperlipidemic status at baseline and 20-year follow-up. Individuals with hyperlipidemia at baseline and/or follow-up had higher apoB levels than those with consistently normal lipids (P<0.05), whereas small LDL size was associated with concurrent hyperlipidemia. Among individuals who were normolipidemic at baseline, the following variables were independently associated with development of hyperlipidemia over 20 years: older age at baseline, male sex, greater increase in BMI during follow-up, and apoE alleles epsilon 2 or epsilon 4. In conclusion, apoB is associated with hyperlipidemia and apoE polymorphism is associated with later onset of hyperlipidemia in FCHL.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0021-9150
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
159
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
471-81
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11730829-Adult,
pubmed-meshheading:11730829-Age Distribution,
pubmed-meshheading:11730829-Apolipoprotein A-I,
pubmed-meshheading:11730829-Apolipoproteins,
pubmed-meshheading:11730829-Child,
pubmed-meshheading:11730829-Cholesterol, HDL,
pubmed-meshheading:11730829-Cholesterol, LDL,
pubmed-meshheading:11730829-Female,
pubmed-meshheading:11730829-Follow-Up Studies,
pubmed-meshheading:11730829-Humans,
pubmed-meshheading:11730829-Hyperlipidemia, Familial Combined,
pubmed-meshheading:11730829-Incidence,
pubmed-meshheading:11730829-Lipoproteins,
pubmed-meshheading:11730829-Longitudinal Studies,
pubmed-meshheading:11730829-Male,
pubmed-meshheading:11730829-Middle Aged,
pubmed-meshheading:11730829-Pedigree,
pubmed-meshheading:11730829-Polymorphism, Genetic,
pubmed-meshheading:11730829-Probability,
pubmed-meshheading:11730829-Prospective Studies,
pubmed-meshheading:11730829-Reference Values,
pubmed-meshheading:11730829-Risk Factors,
pubmed-meshheading:11730829-Sex Distribution
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| pubmed:year |
2001
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| pubmed:articleTitle |
Lipoprotein and apolipoprotein abnormalities in familial combined hyperlipidemia: a 20-year prospective study.
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| pubmed:affiliation |
Department of Medicine, School of Medicine, University of Washington, Box 356429, Seattle, WA 98195, USA. mcneely@u.washington.edu
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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