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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2001-11-30
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pubmed:abstractText |
The role of dopamine in the addictive process (loss of control and compulsive drug intake) is poorly understood. A consistent finding in drug-addicted subjects is a lower level of dopamine D2 receptors. In cocaine abusers, low levels of D2 receptors are associated with a lower level of metabolism in the orbitofrontal cortex. Because the orbitofrontal cortex is associated with compulsive behaviors, its disruption may contribute to compulsive drug intake in addicted subjects. This study explored whether a similar association occurs in methamphetamine abusers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-953X
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pubmed:author |
pubmed-author:ChangLL,
pubmed-author:DingY SYS,
pubmed-author:FowlerJ SJS,
pubmed-author:FranceschiDD,
pubmed-author:GatleyJJ,
pubmed-author:GiffordAA,
pubmed-author:HitzemannRR,
pubmed-author:LoganJJ,
pubmed-author:PappasNN,
pubmed-author:SedlerMM,
pubmed-author:VolkowN DND,
pubmed-author:WangG JGJ,
pubmed-author:WongCC
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pubmed:issnType |
Print
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2015-21
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11729018-Adult,
pubmed-meshheading:11729018-Amphetamine-Related Disorders,
pubmed-meshheading:11729018-Compulsive Behavior,
pubmed-meshheading:11729018-Energy Metabolism,
pubmed-meshheading:11729018-Female,
pubmed-meshheading:11729018-Frontal Lobe,
pubmed-meshheading:11729018-Humans,
pubmed-meshheading:11729018-Male,
pubmed-meshheading:11729018-Methamphetamine,
pubmed-meshheading:11729018-Receptors, Dopamine D2,
pubmed-meshheading:11729018-Risk Factors,
pubmed-meshheading:11729018-Tomography, Emission-Computed
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pubmed:year |
2001
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pubmed:articleTitle |
Low level of brain dopamine D2 receptors in methamphetamine abusers: association with metabolism in the orbitofrontal cortex.
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pubmed:affiliation |
Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. volkow@bnl.gov
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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