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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2001-11-30
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pubmed:abstractText |
Inflammation is a key component of coronary heart disease, and genes coding for cytokines are candidates for predisposing to coronary heart disease risk. We have examined the effect of two polymorphisms (-174G>C and -572G>C) in the promoter of the interleukin-6 (IL-6) gene on risk of coronary heart disease, and on intermediate risk traits including fibrinogen and systolic blood pressure, in 2751 middle-aged healthy U.K. men.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0195-668X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 The European Society of Cardiology.
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2243-52
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11728144-Blood Pressure,
pubmed-meshheading:11728144-Body Mass Index,
pubmed-meshheading:11728144-C-Reactive Protein,
pubmed-meshheading:11728144-Coronary Artery Disease,
pubmed-meshheading:11728144-DNA Primers,
pubmed-meshheading:11728144-European Continental Ancestry Group,
pubmed-meshheading:11728144-Fibrinogen,
pubmed-meshheading:11728144-Genotype,
pubmed-meshheading:11728144-Humans,
pubmed-meshheading:11728144-Interleukin-6,
pubmed-meshheading:11728144-London,
pubmed-meshheading:11728144-Male,
pubmed-meshheading:11728144-Middle Aged,
pubmed-meshheading:11728144-Obesity,
pubmed-meshheading:11728144-Polymorphism, Genetic,
pubmed-meshheading:11728144-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:11728144-Promoter Regions, Genetic,
pubmed-meshheading:11728144-Proportional Hazards Models,
pubmed-meshheading:11728144-Prospective Studies,
pubmed-meshheading:11728144-Reference Values,
pubmed-meshheading:11728144-Risk Factors,
pubmed-meshheading:11728144-Survival Analysis
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pubmed:year |
2001
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pubmed:articleTitle |
The interleukin-6 -174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men.
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pubmed:affiliation |
Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Department of Medicine, Royal Free and University College London Medical School, London, UK.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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