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rdf:type |
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lifeskim:mentions |
umls-concept:C0000768,
umls-concept:C0008059,
umls-concept:C0010802,
umls-concept:C0017337,
umls-concept:C0023449,
umls-concept:C0162789,
umls-concept:C0215508,
umls-concept:C0220901,
umls-concept:C0332466,
umls-concept:C0796520,
umls-concept:C1314939,
umls-concept:C1335654,
umls-concept:C1522609,
umls-concept:C1554112,
umls-concept:C1705326,
umls-concept:C1707520,
umls-concept:C2603343,
umls-concept:C2607943,
umls-concept:C2926606
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pubmed:issue |
12
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pubmed:dateCreated |
2001-11-29
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pubmed:abstractText |
The TEL/AML1 fusion is the most common genetic abnormality found in childhood acute lymphoblastic leukemias (ALL). Although it is very difficult to identify by conventional cytogenetic techniques it can be readily detected using fluorescence in situ hybridization (FISH). We carried out cytogenetic and FISH studies on 42 children with ALL in order to know the frequency of this translocation in our population, the incidence of TEL and/or AML1 gene alterations, and their correlation with clinical evolution and prognosis. In addition, we performed reverse transcription polymerase chain reaction (RT-PCR) in some cases, confirming the feasibility of FISH techniques in the detection of this translocation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 2 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ETS translocation variant 6 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins, Fusion,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/RUNX1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TEL-AML1 fusion protein,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0390-6078
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pubmed:author |
pubmed-author:BenítezJJ,
pubmed-author:BernacerMM,
pubmed-author:CantalejoAA,
pubmed-author:CigudosaJ CJC,
pubmed-author:ContraTT,
pubmed-author:López-IborBB,
pubmed-author:Martínez-RamírezAA,
pubmed-author:PortersJ EJE,
pubmed-author:SotoCC,
pubmed-author:TavaresAA,
pubmed-author:UriosteMM
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1245-53
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11726315-Adolescent,
pubmed-meshheading:11726315-Bone Marrow,
pubmed-meshheading:11726315-Child,
pubmed-meshheading:11726315-Child, Preschool,
pubmed-meshheading:11726315-Chromosome Aberrations,
pubmed-meshheading:11726315-Core Binding Factor Alpha 2 Subunit,
pubmed-meshheading:11726315-Cytogenetic Analysis,
pubmed-meshheading:11726315-DNA-Binding Proteins,
pubmed-meshheading:11726315-Female,
pubmed-meshheading:11726315-Gene Dosage,
pubmed-meshheading:11726315-Humans,
pubmed-meshheading:11726315-In Situ Hybridization, Fluorescence,
pubmed-meshheading:11726315-Male,
pubmed-meshheading:11726315-Oncogene Proteins, Fusion,
pubmed-meshheading:11726315-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:11726315-Prognosis,
pubmed-meshheading:11726315-Proto-Oncogene Proteins,
pubmed-meshheading:11726315-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:11726315-Repressor Proteins,
pubmed-meshheading:11726315-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Fluorescence in situ hybridization study of TEL/AML1 fusion and other abnormalities involving TEL and AML1 genes. Correlation with cytogenetic findings and prognostic value in children with acute lymphocytic leukemia.
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pubmed:affiliation |
Dpto. de Genética Humana, Programa de Patología Molecular, Centro Nacional de Investigaciones Oncológicas (CNIO), Ctra. Majadahonda-Pozuelo, Km. 2, 28220 Majadahonda, Madrid, Spain. angmartinez@cnio.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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