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rdf:type |
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lifeskim:mentions |
umls-concept:C0001186,
umls-concept:C0007625,
umls-concept:C0010934,
umls-concept:C0013343,
umls-concept:C0023516,
umls-concept:C0028606,
umls-concept:C0205307,
umls-concept:C0220781,
umls-concept:C0341628,
umls-concept:C0439849,
umls-concept:C0439861,
umls-concept:C0445223,
umls-concept:C0682538,
umls-concept:C1261322,
umls-concept:C1280500,
umls-concept:C1552599,
umls-concept:C1704787
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pubmed:issue |
16
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pubmed:dateCreated |
1975-12-12
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pubmed:abstractText |
Acridine dyes inhibit the incorporation of 3H-thymidine and 3H-uridine in intact cells to the same extent as Actinomycin D. In contrast to Actinomycin D, RNA synthesis by DNA - dependent RNA polymerase in a cell-free system is inhibited at lo2 higher concentrations of acridine dyes, only. Possible differential effects on the cell membrane resulting in decreased intracellular pools of uridine and thymidine are discussed.
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pubmed:language |
ger
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acridines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Directed RNA Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/Dactinomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Proflavine,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium,
http://linkedlifedata.com/resource/pubmed/chemical/Uridine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0023-2173
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
783-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1172598-Acridines,
pubmed-meshheading:1172598-Animals,
pubmed-meshheading:1172598-Cell Membrane,
pubmed-meshheading:1172598-Cell-Free System,
pubmed-meshheading:1172598-Cells, Cultured,
pubmed-meshheading:1172598-DNA,
pubmed-meshheading:1172598-DNA, Neoplasm,
pubmed-meshheading:1172598-DNA-Directed RNA Polymerases,
pubmed-meshheading:1172598-Dactinomycin,
pubmed-meshheading:1172598-Friend murine leukemia virus,
pubmed-meshheading:1172598-Humans,
pubmed-meshheading:1172598-Leukemia,
pubmed-meshheading:1172598-Leukocytes,
pubmed-meshheading:1172598-Mice,
pubmed-meshheading:1172598-Nucleic Acids,
pubmed-meshheading:1172598-Proflavine,
pubmed-meshheading:1172598-RNA,
pubmed-meshheading:1172598-RNA, Neoplasm,
pubmed-meshheading:1172598-Subcellular Fractions,
pubmed-meshheading:1172598-Thymidine,
pubmed-meshheading:1172598-Tritium,
pubmed-meshheading:1172598-Uridine
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pubmed:year |
1975
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pubmed:articleTitle |
[The effect of actinomycin d, acridine dyes and related substances on the biosynthesis of nucleic acids in normal and leukemic white blood cells. Comparative investigation in intact cells and in a cell-free system (author's transl)].
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pubmed:publicationType |
Journal Article,
English Abstract
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