|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
12
|
|
pubmed:dateCreated |
2001-11-27
|
|
pubmed:abstractText |
The effect of tramadol on the plasma glucose level of streptozotocin (STZ)-induced diabetic rats was investigated. A dose-dependent lowering of plasma glucose was seen in the fasting STZ-induced diabetic rats 30 min after intravenous injection of tramadol. This effect of tramadol was abolished by pretreatment with naloxone or naloxonazine at doses sufficient to block opioid mu-receptors. However, response to tramadol was not changed in STZ-induced diabetic rats receiving p-chlorophenylalanine at a dose sufficient to deplete endogenous 5-hydroxytrptamine (5-HT). Therefore, mediation of 5-HT in this action of tramadol is ruled out. In isolated soleus muscle, tramadol enhanced the uptake of radioactive glucose in a concentration-dependent manner. The stimulatory effects of tramadol on glycogen synthesis were also seen in hepatocytes isolated from STZ-induced diabetic rats. The blockade of these actions by naloxone and naloxonazine indicated the mediation of opioid mu-receptors. The mRNA and protein levels of the subtype 4 form of glucose transporter in soleus muscle were increased after repeated treatments for 4 days with tramadol in STZ-induced diabetic rats. Moreover, similar repeated treatments with tramadol reversed the elevated mRNA and protein levels of phosphoenolpyruvate carboxykinase in the liver of STZ-induced diabetic rats. These results suggest that activation of opioid mu-receptors by tramadol can increase the utilization of glucose and/or decrease hepatic gluconeogenesis to lower plasma glucose in diabetic rats lacking insulin.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 4,
http://linkedlifedata.com/resource/pubmed/chemical/Glycogen,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Naloxone,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotics,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoenolpyruvate Carboxykinase...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/Slc2a4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Tramadol,
http://linkedlifedata.com/resource/pubmed/chemical/naloxonazine
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0012-1797
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
50
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2815-21
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11723065-Animals,
pubmed-meshheading:11723065-Blood Glucose,
pubmed-meshheading:11723065-Diabetes Mellitus, Experimental,
pubmed-meshheading:11723065-Dose-Response Relationship, Drug,
pubmed-meshheading:11723065-Gluconeogenesis,
pubmed-meshheading:11723065-Glucose,
pubmed-meshheading:11723065-Glucose Transporter Type 4,
pubmed-meshheading:11723065-Glycogen,
pubmed-meshheading:11723065-Hypoglycemic Agents,
pubmed-meshheading:11723065-Injections, Intravenous,
pubmed-meshheading:11723065-Kinetics,
pubmed-meshheading:11723065-Liver,
pubmed-meshheading:11723065-Male,
pubmed-meshheading:11723065-Monosaccharide Transport Proteins,
pubmed-meshheading:11723065-Muscle, Skeletal,
pubmed-meshheading:11723065-Muscle Proteins,
pubmed-meshheading:11723065-Naloxone,
pubmed-meshheading:11723065-Narcotic Antagonists,
pubmed-meshheading:11723065-Narcotics,
pubmed-meshheading:11723065-Phosphoenolpyruvate Carboxykinase (GTP),
pubmed-meshheading:11723065-RNA, Messenger,
pubmed-meshheading:11723065-Rats,
pubmed-meshheading:11723065-Rats, Wistar,
pubmed-meshheading:11723065-Receptors, Opioid, mu,
pubmed-meshheading:11723065-Tramadol
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Plasma glucose-lowering effect of tramadol in streptozotocin-induced diabetic rats.
|
|
pubmed:affiliation |
Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan. jtcheng@mail.ncku.edu.tw
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
