| pubmed-article:11721745 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11721745 | lifeskim:mentions | umls-concept:C0009938 | lld:lifeskim |
| pubmed-article:11721745 | lifeskim:mentions | umls-concept:C1882864 | lld:lifeskim |
| pubmed-article:11721745 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11721745 | lifeskim:mentions | umls-concept:C1332397 | lld:lifeskim |
| pubmed-article:11721745 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11721745 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11721745 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:11721745 | pubmed:dateCreated | 2001-11-27 | lld:pubmed |
| pubmed-article:11721745 | pubmed:abstractText | After contusion-derived spinal cord injury, (SCI) there is localized tissue disruption and energy failure that results in early necrosis and delayed apoptosis, events that contribute to chronic central pain in a majority of patients. We assessed the extent of contusion-induced apoptosis of neurons in a known central pain-signaling pathway, the spinothalamic tract (STT), which may be a contributor to SCI-induced pain. We observed the loss of STT cells and localized increase of DNA fragmentation and cytoplasmic histone-DNA complexes, which suggested potential apoptotic changes among STT neurons after SCI. We also showed SCI-associated changes in the expression of the antiapoptotic protein Bcl-xL, especially among STT cells, consistent with the hypothesis that Bcl-xL regulates the extent of apoptosis after SCI. Apoptosis in the injured spinal cord correlated well with prompt decreases in Bcl-xL protein levels and Bcl-xL/Bax protein ratios at the contusion site. We interpret these results as evidence that regulation of Bcl-xL may play a role in neural sparing after spinal injury and pain-signaling function. | lld:pubmed |
| pubmed-article:11721745 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11721745 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11721745 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11721745 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11721745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11721745 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11721745 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11721745 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11721745 | pubmed:issn | 0897-7151 | lld:pubmed |
| pubmed-article:11721745 | pubmed:author | pubmed-author:Perez-PoloJ... | lld:pubmed |
| pubmed-article:11721745 | pubmed:author | pubmed-author:YuJJ | lld:pubmed |
| pubmed-article:11721745 | pubmed:author | pubmed-author:WestlundK NKN | lld:pubmed |
| pubmed-article:11721745 | pubmed:author | pubmed-author:McAdooDD | lld:pubmed |
| pubmed-article:11721745 | pubmed:author | pubmed-author:ReeTT | lld:pubmed |
| pubmed-article:11721745 | pubmed:author | pubmed-author:HulseboschC... | lld:pubmed |
| pubmed-article:11721745 | pubmed:author | pubmed-author:QiuJJ | lld:pubmed |
| pubmed-article:11721745 | pubmed:author | pubmed-author:BoeEE | lld:pubmed |
| pubmed-article:11721745 | pubmed:author | pubmed-author:NesicOO | lld:pubmed |
| pubmed-article:11721745 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11721745 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:11721745 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11721745 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11721745 | pubmed:pagination | 1267-78 | lld:pubmed |
| pubmed-article:11721745 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11721745 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11721745 | pubmed:articleTitle | Bcl-xL expression after contusion to the rat spinal cord. | lld:pubmed |
| pubmed-article:11721745 | pubmed:affiliation | Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, USA. | lld:pubmed |
| pubmed-article:11721745 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11721745 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11721745 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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