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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2001-11-27
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pubmed:abstractText |
After contusion-derived spinal cord injury, (SCI) there is localized tissue disruption and energy failure that results in early necrosis and delayed apoptosis, events that contribute to chronic central pain in a majority of patients. We assessed the extent of contusion-induced apoptosis of neurons in a known central pain-signaling pathway, the spinothalamic tract (STT), which may be a contributor to SCI-induced pain. We observed the loss of STT cells and localized increase of DNA fragmentation and cytoplasmic histone-DNA complexes, which suggested potential apoptotic changes among STT neurons after SCI. We also showed SCI-associated changes in the expression of the antiapoptotic protein Bcl-xL, especially among STT cells, consistent with the hypothesis that Bcl-xL regulates the extent of apoptosis after SCI. Apoptosis in the injured spinal cord correlated well with prompt decreases in Bcl-xL protein levels and Bcl-xL/Bax protein ratios at the contusion site. We interpret these results as evidence that regulation of Bcl-xL may play a role in neural sparing after spinal injury and pain-signaling function.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0897-7151
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1267-78
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11721745-Animals,
pubmed-meshheading:11721745-Apoptosis,
pubmed-meshheading:11721745-Blotting, Western,
pubmed-meshheading:11721745-Contusions,
pubmed-meshheading:11721745-DNA,
pubmed-meshheading:11721745-DNA Fragmentation,
pubmed-meshheading:11721745-Fluorescent Antibody Technique, Direct,
pubmed-meshheading:11721745-Histones,
pubmed-meshheading:11721745-Locomotion,
pubmed-meshheading:11721745-Male,
pubmed-meshheading:11721745-Microscopy, Confocal,
pubmed-meshheading:11721745-Pain,
pubmed-meshheading:11721745-Proto-Oncogene Proteins,
pubmed-meshheading:11721745-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:11721745-Rats,
pubmed-meshheading:11721745-Rats, Sprague-Dawley,
pubmed-meshheading:11721745-Spinal Cord,
pubmed-meshheading:11721745-Spinal Cord Injuries,
pubmed-meshheading:11721745-Spinothalamic Tracts,
pubmed-meshheading:11721745-bcl-2-Associated X Protein,
pubmed-meshheading:11721745-bcl-X Protein
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pubmed:year |
2001
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pubmed:articleTitle |
Bcl-xL expression after contusion to the rat spinal cord.
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pubmed:affiliation |
Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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