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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-11-23
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pubmed:abstractText |
In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass accrual during growth. Mutations in LRP5 cause the autosomal recessive disorder osteoporosis-pseudoglioma syndrome (OPPG). We find that OPPG carriers have reduced bone mass when compared to age- and gender-matched controls. We demonstrate LRP5 expression by osteoblasts in situ and show that LRP5 can transduce Wnt signaling in vitro via the canonical pathway. We further show that a mutant-secreted form of LRP5 can reduce bone thickness in mouse calvarial explant cultures. These data indicate that Wnt-mediated signaling via LRP5 affects bone accrual during growth and is important for the establishment of peak bone mass.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/BMP2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bmp2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/LDL-Receptor Related Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/LRP5 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Low Density Lipoprotein...,
http://linkedlifedata.com/resource/pubmed/chemical/Lrp5 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/WNT4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/WNT5A protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt4 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/dishevelled proteins,
http://linkedlifedata.com/resource/pubmed/chemical/recombinant human bone...
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:SullivanBB,
pubmed-author:SteinmannBB,
pubmed-author:HiroseTT,
pubmed-author:JüppnerHH,
pubmed-author:GlorieuxF HFH,
pubmed-author:BorroneCC,
pubmed-author:HaldJJ,
pubmed-author:DallapiccolaBB,
pubmed-author:BeightonPP,
pubmed-author:LambertMM,
pubmed-author:FUL JLJ,
pubmed-author:AllgroveJJ,
pubmed-author:CundyTT,
pubmed-author:PeltonenLL,
pubmed-author:BaronRR,
pubmed-author:WangHH,
pubmed-author:SomerHH,
pubmed-author:ZabelBB,
pubmed-author:SwobodaWW,
pubmed-author:OlsenB RBR,
pubmed-author:VotrubaMM,
pubmed-author:AdkinsW NWN,
pubmed-author:GarciaTT,
pubmed-author:GoodEE,
pubmed-author:MarcelinoJJ,
pubmed-author:BatchJ AJA,
pubmed-author:Van HulWW,
pubmed-author:De PaepeAA,
pubmed-author:Roman-RomanSS,
pubmed-author:CarleG FGF,
pubmed-author:HennekamR CRC,
pubmed-author:BrunnerH GHG,
pubmed-author:KimC ACA,
pubmed-author:ReginatoA MAM,
pubmed-author:JangMM,
pubmed-author:OexleKK,
pubmed-author:Steichen-GersdorfEE,
pubmed-author:Superti-FurgaAA,
pubmed-author:BolesR GRG,
pubmed-author:ApteSS,
pubmed-author:VikkulaMM,
pubmed-author:FukaiNN,
pubmed-author:RamesarR SRS,
pubmed-author:BlackG CGC,
pubmed-author:HeegerSS,
pubmed-author:KohlschuetterAA,
pubmed-author:Arslan-KirchnerMM,
pubmed-author:ZacharisHH,
pubmed-author:WarmanM LML,
pubmed-author:RawadiGG,
pubmed-author:van den BoogaardM JMJ,
pubmed-author:BoonL MLM,
pubmed-author:SabatakosGG,
pubmed-author:LetteboerTT
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