| pubmed-article:11719190 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11719190 | lifeskim:mentions | umls-concept:C1947953 | lld:lifeskim |
| pubmed-article:11719190 | lifeskim:mentions | umls-concept:C0017982 | lld:lifeskim |
| pubmed-article:11719190 | lifeskim:mentions | umls-concept:C1517880 | lld:lifeskim |
| pubmed-article:11719190 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11719190 | lifeskim:mentions | umls-concept:C2700372 | lld:lifeskim |
| pubmed-article:11719190 | lifeskim:mentions | umls-concept:C0969146 | lld:lifeskim |
| pubmed-article:11719190 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11719190 | pubmed:dateCreated | 2001-11-23 | lld:pubmed |
| pubmed-article:11719190 | pubmed:abstractText | The functional consequences of glycan structural changes associated with cellular differentiation are ill defined. Herein, we investigate the role of glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8alphabeta coreceptor to the thymocyte surface. We show that immature CD4(+)CD8(+) double-positive thymocytes bind MHCI tetramers more avidly than mature CD8 single-positive thymocytes, and that this differential binding is governed by developmentally programmed O-glycan modification controlled by the ST3Gal-I sialyltransferase. ST3Gal-I induction and attendant core 1 sialic acid addition to CD8beta on mature thymocytes decreases CD8alphabeta-MHCI avidity by altering CD8alphabeta domain-domain association and/or orientation. Hence, glycans on the CD8beta stalk appear to modulate the ability of the distal binding surface of the dimeric CD8 globular head domains to clamp MHCI. | lld:pubmed |
| pubmed-article:11719190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11719190 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11719190 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11719190 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11719190 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:11719190 | pubmed:author | pubmed-author:RaevuoriMM | lld:pubmed |
| pubmed-article:11719190 | pubmed:author | pubmed-author:ReinherzE LEL | lld:pubmed |
| pubmed-article:11719190 | pubmed:author | pubmed-author:ChuiDD | lld:pubmed |
| pubmed-article:11719190 | pubmed:author | pubmed-author:MoodyA MAM | lld:pubmed |
| pubmed-article:11719190 | pubmed:author | pubmed-author:PriatelJ JJJ | lld:pubmed |
| pubmed-article:11719190 | pubmed:author | pubmed-author:RecheP APA | lld:pubmed |
| pubmed-article:11719190 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11719190 | pubmed:day | 16 | lld:pubmed |
| pubmed-article:11719190 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:11719190 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11719190 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11719190 | pubmed:pagination | 501-12 | lld:pubmed |
| pubmed-article:11719190 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:meshHeading | pubmed-meshheading:11719190... | lld:pubmed |
| pubmed-article:11719190 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11719190 | pubmed:articleTitle | Developmentally regulated glycosylation of the CD8alphabeta coreceptor stalk modulates ligand binding. | lld:pubmed |
| pubmed-article:11719190 | pubmed:affiliation | Laboratory of Immunobiology, Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:11719190 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11719190 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11719190 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11719190 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:12525 | entrezgene:pubmed | pubmed-article:11719190 | lld:entrezgene |
| entrez-gene:12526 | entrezgene:pubmed | pubmed-article:11719190 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11719190 | lld:pubmed |
