11718549

Source:http://linkedlifedata.com/resource/pubmed/id/11718549

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0033809, umls-concept:C0081786, umls-concept:C0085469
pubmed:issue	10
pubmed:dateCreated	2001-11-22
pubmed:abstractText	The leading cause of morbidity and mortality in cystic fibrosis (CF) continues to be lung infections with Pseudomonas aeruginosa biofilms. Co-colonization of the lungs with P aeruginosa and Burkholderia cepacia can result in more severe pulmonary disease than P. aeruginosa alone. The interactions between P. aeruginosa biofilms and B. cepacia are not yet understood; one possible association being that mixed species biofilm formation may be part of the interspecies relationship. Using the Calgary Biofilm Device (CBD), members of all genomovars of the B. cepacia complex were shown to form biofilms, including those isolated from CF lungs. Mixed species biofilm formation between CF isolates of P. aeruginosa and B. cepacia was readily achieved using the CBD. Oxidation-fermentation lactose agar was adapted as a differential agar to monitor mixed biofilm composition. Scanning electron micrographs of the biofilms demonstrated that both species readily integrated in close association in the biofilm structure. Pseudomonas aeruginosa laboratory strain PAO1, however, inhibited mixed biofilm formation of both CF isolates and environmental strains of the B. cepacia complex. Characterization of the soluble inhibitor suggested pyocyanin as the active compound.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0372707
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0008-4166
pubmed:author	pubmed-author:CeriHH, pubmed-author:CollO POP, pubmed-author:TomlinK LKL
pubmed:issnType	Print
pubmed:volume	47
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	949-54
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:11718549-Biofilms, pubmed-meshheading:11718549-Burkholderia cepacia, pubmed-meshheading:11718549-Cystic Fibrosis, pubmed-meshheading:11718549-Humans, pubmed-meshheading:11718549-Pseudomonas aeruginosa
pubmed:year	2001
pubmed:articleTitle	Interspecies biofilms of Pseudomonas aeruginosa and Burkholderia cepacia.
pubmed:affiliation	Department of Biological Sciences, University of Calgary, AB, Canada.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't