Source:http://linkedlifedata.com/resource/pubmed/id/11715070
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2001-11-20
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| pubmed:abstractText |
Wegener's granulomatosis is a granulomatous and vasculitic disease of unknown origin. Gene polymorphisms are known to affect phenotypes of numerous diseases. Polymorphisms within the angiotensin-converting enzyme (ACE), transforming growth factor-beta1 (TGF-beta1), and interleukin-10 (IL-10) genes are suspected to modify the course of granulomatous disorders. We examined whether the genotype frequencies of the named polymorphisms differ in Wegener's granulomatosis from those in healthy controls. Thirty-nine patients with Wegener's granulomatosis were genotyped for the deletion/insertion polymorphism in intron 16 of the ACE gene, a biallelic polymorphism in codon 25 of the TGF-beta1 gene and a biallelic polymorphism at position -1082 of the IL-10 gene and compared with healthy blood donors. For the ACE polymorphism no significant differences were detected neither in the allele frequencies nor in the genotype frequencies. For TGF-beta1 a trend to genotype CG was found. The most interesting result was the observed, significant shift to genotype AA of the IL-10 polymorphism in Wegener's granulomatosis. IL-10 and TGF-beta1, immunoregulatory cytokines capable of down-regulating T helper cell type 1 response, showed a significant shift or a trend, respectively towards genotypes associated with reduced cytokine release, leading to the hypothesis that different immunoregulatory cytokine patterns dependent on gene polymorphisms might be involved in the pathogenesis of Wegener's granulomatosis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Codon,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl-Dipeptidase A,
http://linkedlifedata.com/resource/pubmed/chemical/TGFB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0946-2716
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
79
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
665-70
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| pubmed:dateRevised |
2011-7-8
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| pubmed:meshHeading |
pubmed-meshheading:11715070-Adult,
pubmed-meshheading:11715070-Alleles,
pubmed-meshheading:11715070-Case-Control Studies,
pubmed-meshheading:11715070-Codon,
pubmed-meshheading:11715070-Cytokines,
pubmed-meshheading:11715070-Down-Regulation,
pubmed-meshheading:11715070-Female,
pubmed-meshheading:11715070-Gene Deletion,
pubmed-meshheading:11715070-Genotype,
pubmed-meshheading:11715070-Humans,
pubmed-meshheading:11715070-Interleukin-10,
pubmed-meshheading:11715070-Introns,
pubmed-meshheading:11715070-Male,
pubmed-meshheading:11715070-Middle Aged,
pubmed-meshheading:11715070-Peptidyl-Dipeptidase A,
pubmed-meshheading:11715070-Polymerase Chain Reaction,
pubmed-meshheading:11715070-Polymorphism, Genetic,
pubmed-meshheading:11715070-T-Lymphocytes,
pubmed-meshheading:11715070-Transforming Growth Factor beta,
pubmed-meshheading:11715070-Transforming Growth Factor beta1,
pubmed-meshheading:11715070-Wegener Granulomatosis
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| pubmed:year |
2001
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| pubmed:articleTitle |
Gene polymorphisms of immunoregulatory cytokines and angiotensin-converting enzyme in Wegener's granulomatosis.
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| pubmed:affiliation |
Research Center Borstel, Medical Hospital, Parkallee 35, 23845 Borstel, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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