Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-11-6
pubmed:abstractText
Butaclamol hydrochloride (AY-23,028) is a member of a new chemical class for which antipsychotic activity in humans has recently been demonstrated. The compound antagonized amphetamine-induced stereotyped behavior in rats, amphetamine toxicity in aggregated mice and apomorphine-induced emesis in dogs. It depressed both discriminated avoidance and continuous lever-pressing behavior in rats and inhibited ambulation and rearing in the open field. At higher doses, AY-23,028 induced catalepsy. Adrenergic blocking activity, measured by the antagonism of epinephrine-induced mortality, was weak. These pharmacological actions are characteristic of neuroleptic drugs. In the dose range where the aforementioned effects were observed AY-23,028 did not antagonize either the tetrabenazine-induced ptosis or the tremorine syndrome and did not cause either hypothermia or ataxia. The potency and onset of action of AY-23,028 were comparable to those of fluphenazine but AY-23,028 was of longer duration. The results are discussed in relation to current concepts of neuroleptic mechanisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0033-3158
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11-20
pubmed:dateRevised
2009-10-27
pubmed:meshHeading
pubmed-meshheading:1171496-Amphetamine, pubmed-meshheading:1171496-Animals, pubmed-meshheading:1171496-Apomorphine, pubmed-meshheading:1171496-Avoidance Learning, pubmed-meshheading:1171496-Behavior, Animal, pubmed-meshheading:1171496-Catalepsy, pubmed-meshheading:1171496-Chlorpromazine, pubmed-meshheading:1171496-Dextroamphetamine, pubmed-meshheading:1171496-Dibenzocycloheptenes, pubmed-meshheading:1171496-Discrimination Learning, pubmed-meshheading:1171496-Dogs, pubmed-meshheading:1171496-Epinephrine, pubmed-meshheading:1171496-Fluphenazine, pubmed-meshheading:1171496-Humans, pubmed-meshheading:1171496-Male, pubmed-meshheading:1171496-Mice, pubmed-meshheading:1171496-Motor Activity, pubmed-meshheading:1171496-Quinolizines, pubmed-meshheading:1171496-Rats, pubmed-meshheading:1171496-Stereotyped Behavior, pubmed-meshheading:1171496-Tranquilizing Agents, pubmed-meshheading:1171496-Vomiting
pubmed:year
1975
pubmed:articleTitle
The behavioral pharmacology of butaclamol hydrochloride (AY-23,028), a new potent neuroleptic drug.
pubmed:publicationType
Journal Article, Comparative Study