Linked Life Data

11714857

Source:http://linkedlifedata.com/resource/pubmed/id/11714857

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-11-20
pubmed:abstractText
The contribution of 17 polymorphisms within 13 candidate genes on lipid trait variability was investigated by a multiplex assay in 772 men and 780 women coming for a health checkup examination. The studied genes were APOE, APOB, APOC3, CETP, LPL, PON, MTHFR, FGB, GpIIIa, SELE, ACE, and AGT. We found that APOB-Thr71Ile, APOE-(112/158), APOC3-1100C/T, and SELE-98G/T polymorphisms had a significant effect on lipid traits (P < or = 0.001 to P < or = 0.01). Genetic effects accounted for 3.5-5.7% of variation in apolipoprotein B (apoB)-related traits among men, and for 5.7-9.0% among women. The contribution of APOE polymorphism on apoB-related traits variability was two to three times more important in women than in men. We found suggestive evidence for interactive effects between genetics and age, smoking status, and oral contraceptives. Increase of LDL-cholesterol and apoB concentrations with age was stronger among the epsilon4 carriers in women, and apolipoprotein A-I (apoA-I) concentration decreased with age in epsilon4 male carriers. The effect of epsilon2 allele on LDL-cholesterol was more important in the oral contraceptive users. In nonsmokers only, the APOC3-1100C allele in women was related to lower apoB-related traits concentrations, and in men to higher apoA-I and HDL-cholesterol concentrations. In conclusion, this work, in addition to the reinforcement of the already known associations between APOB, APOE, and APOC3 genes and lipids, leads to new perspectives in the complex relationships among genes and environmental factors. The newly observed relationships between E-selectine gene and lipid concentrations support the hypotheses of multiple metabolic pathways contributing to the complexity of lipids variability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1879-90
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11714857-Adult, pubmed-meshheading:11714857-Aging, pubmed-meshheading:11714857-Alleles, pubmed-meshheading:11714857-Apolipoprotein A-I, pubmed-meshheading:11714857-Apolipoprotein C-III, pubmed-meshheading:11714857-Apolipoproteins B, pubmed-meshheading:11714857-Apolipoproteins C, pubmed-meshheading:11714857-Apolipoproteins E, pubmed-meshheading:11714857-Cholesterol, LDL, pubmed-meshheading:11714857-Codon, pubmed-meshheading:11714857-Cohort Studies, pubmed-meshheading:11714857-Contraceptives, Oral, pubmed-meshheading:11714857-Female, pubmed-meshheading:11714857-Genetic Variation, pubmed-meshheading:11714857-Humans, pubmed-meshheading:11714857-Lipid Metabolism, pubmed-meshheading:11714857-Lipids, pubmed-meshheading:11714857-Male, pubmed-meshheading:11714857-Middle Aged, pubmed-meshheading:11714857-Polymorphism, Genetic, pubmed-meshheading:11714857-Sex Characteristics, pubmed-meshheading:11714857-Smoking
pubmed:year
2001
pubmed:articleTitle
Genetic influences on lipid metabolism trait variability within the Stanislas Cohort.
pubmed:affiliation
Institut National de la Sante et de la Recherche Médicale U525, 2 Avenue du Doyen Jacques Parisot, 54501 Vandoeuvre-lès-Nancy, France-Université Henri Poincaré, Nancy I, 30 Rue Lionnois, 54000 Nancy, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't