Linked Life Data

11714852

Source:http://linkedlifedata.com/resource/pubmed/id/11714852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-11-20
pubmed:abstractText
This study investigates the importance of peroxisome proliferator activated receptor alpha (PPARalpha) for serum apolipoprotein B (apoB) levels and hepatic secretion of apoB-containing lipoproteins. Total serum apoB and VLDL-apoB levels were higher in female PPARalpha-null mice compared with female wild-type mice, but no difference was seen in male mice. Furthermore, hepatic triglyceride secretion rate, determined in vivo after Triton WR1339 injection, was 2.4-fold higher in female PPARalpha-null mice compared with female wild-type mice, but no difference was observed in male mice. However, when fed a high fat diet, male PPARalpha-null mice displayed 2-fold higher serum levels of apoB and LDL cholesterol compared with male wild-type mice, but triglyceride levels were not affected. Hepatic LDL receptor protein levels were not influenced by PPARalpha deficiency, gender, or the fat diet. Hepatocyte cultures from female PPARalpha-null mice (cultured for 4 days in serum free medium) showed 2-fold higher total apoB secretion and increased secretion of apoB-48 VLDL, as well as 2.7-fold larger accumulation of VLDL-triglycerides in the medium compared with wild-type cultures. In conclusion, PPARalpha-deficient female mice, but not males, display high serum apoB associated with VLDL and increased hepatic triglyceride secretion. Moreover, male PPARalpha-null mice show increased susceptibility to high fat diet in terms of serum apoB levels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1831-40
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11714852-Animals, pubmed-meshheading:11714852-Apolipoproteins B, pubmed-meshheading:11714852-Blotting, Western, pubmed-meshheading:11714852-Cells, Cultured, pubmed-meshheading:11714852-Cholesterol, pubmed-meshheading:11714852-Cholesterol, LDL, pubmed-meshheading:11714852-Dietary Fats, pubmed-meshheading:11714852-Lipoproteins, pubmed-meshheading:11714852-Lipoproteins, VLDL, pubmed-meshheading:11714852-Liver, pubmed-meshheading:11714852-Mice, pubmed-meshheading:11714852-Mice, Inbred C57BL, pubmed-meshheading:11714852-Mice, Knockout, pubmed-meshheading:11714852-RNA, Messenger, pubmed-meshheading:11714852-Receptors, Cytoplasmic and Nuclear, pubmed-meshheading:11714852-Receptors, LDL, pubmed-meshheading:11714852-Transcription Factors, pubmed-meshheading:11714852-Triglycerides
pubmed:year
2001
pubmed:articleTitle
PPARalpha deficiency increases secretion and serum levels of apolipoprotein B-containing lipoproteins.
pubmed:affiliation
Department of Physiology, University of Göteborg, Box 434, S-405 30 Göteborg, Sweden. daniel.linden@fysiologi.gu.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't