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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0086418,
umls-concept:C0330390,
umls-concept:C0597357,
umls-concept:C1171362,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1425360,
umls-concept:C1515655,
umls-concept:C1515670,
umls-concept:C1706438,
umls-concept:C2003941,
umls-concept:C2698600
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pubmed:issue |
11
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pubmed:dateCreated |
2001-11-20
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pubmed:abstractText |
The membrane receptor 2B4 is a CD2 family member that is involved in lymphocyte activation. A fraction of human CD8+ alphabeta T cells up-regulate 2B4 in vivo, and here we demonstrate that this correlates with the acquisition of effector cell properties such as granzyme B and perforin expression, rapid IFN-gamma production, and down-regulation of the lymph node homing chemokine receptor CCR7. In PBLs from healthy donors, cytomegalovirus-specific effector T cells were 2B4 positive, whereas naive melanoma Ag (Melan-A/melanoma Ag recognized by T cells-1)-specific T cells were 2B4 negative. In melanoma patients, Melan-A-specific T cells up-regulated 2B4 in parallel with in vivo differentiation. This occurred in PBLs after vaccination with Melan-A peptides and in tumor-infiltrated lymph nodes, likely through disease-associated activation of Melan-A-specific T cells. Thus, 2B4 expression correlates with CD8+ T cell differentiation in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/CD244 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cancer Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/GZMB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Granzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/MART-1 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MLANA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Perforin,
http://linkedlifedata.com/resource/pubmed/chemical/Pore Forming Cytotoxic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:AyyoubMM,
pubmed-author:BatardPP,
pubmed-author:CellaMM,
pubmed-author:CerottiniJ CJC,
pubmed-author:ColonnaMM,
pubmed-author:GuillaumePP,
pubmed-author:LiénardDD,
pubmed-author:PittetM JMJ,
pubmed-author:RomeroPP,
pubmed-author:SpeiserD EDE,
pubmed-author:ValmoriDD
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6165-70
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11714776-Antigens, CD,
pubmed-meshheading:11714776-Antigens, Neoplasm,
pubmed-meshheading:11714776-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11714776-Cancer Vaccines,
pubmed-meshheading:11714776-Cell Differentiation,
pubmed-meshheading:11714776-Cell Separation,
pubmed-meshheading:11714776-Epitopes, T-Lymphocyte,
pubmed-meshheading:11714776-Granzymes,
pubmed-meshheading:11714776-Humans,
pubmed-meshheading:11714776-Interferon-gamma,
pubmed-meshheading:11714776-Interphase,
pubmed-meshheading:11714776-Lymphocyte Activation,
pubmed-meshheading:11714776-MART-1 Antigen,
pubmed-meshheading:11714776-Melanoma,
pubmed-meshheading:11714776-Membrane Glycoproteins,
pubmed-meshheading:11714776-Neoplasm Proteins,
pubmed-meshheading:11714776-Perforin,
pubmed-meshheading:11714776-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:11714776-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:11714776-Receptors, Immunologic,
pubmed-meshheading:11714776-Serine Endopeptidases,
pubmed-meshheading:11714776-T-Lymphocyte Subsets,
pubmed-meshheading:11714776-Up-Regulation
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pubmed:year |
2001
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pubmed:articleTitle |
The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells.
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pubmed:affiliation |
Division of Clinical Onco-Immunology, Ludwig Institute for Cancer Research, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. daniel.speiser@hospvd.ch
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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