Source:http://linkedlifedata.com/resource/pubmed/id/11714762
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2001-11-20
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pubmed:abstractText |
Better knowledge of peripheral B lymphocyte homeostasis is needed to address the human hypogammaglobulinemia diseases. A defect in the Bcmd gene shortens the B cell life span and causes B cell deficiency in A/WySnJ mice. Previous genetic mapping placed Bcmd near Srebf2 on chromosome 15. Inspection of the human chromosome 22 syntenic region identified the proapoptotic Bik gene as a candidate. Two mapping methods placed the homologous mouse gene, Blk, near Srebf2. The Blk genomic structure was highly homologous to BIK: Sequence analysis ruled out coding region mutations, but Blk transcripts were overly abundant in sorted A/WySnJ T1 B cells. Moreover, enriched transitional B cells showed a cell-autonomous defect leading to excessive apoptosis. Thus, Bcmd may be a direct mutation in Blk, or in a gene involved in Blk regulation, such that excess expression pushes the A/WySnJ transitional B cells past the apoptosis checkpoint to cell death.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Biklk protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
167
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6069-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11714762-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11714762-Animals,
pubmed-meshheading:11714762-Apoptosis,
pubmed-meshheading:11714762-B-Lymphocyte Subsets,
pubmed-meshheading:11714762-Carrier Proteins,
pubmed-meshheading:11714762-Cells, Cultured,
pubmed-meshheading:11714762-Gene Expression Regulation,
pubmed-meshheading:11714762-Humans,
pubmed-meshheading:11714762-Mice,
pubmed-meshheading:11714762-Mice, Inbred A,
pubmed-meshheading:11714762-Mitochondrial Proteins,
pubmed-meshheading:11714762-Polymorphism, Genetic,
pubmed-meshheading:11714762-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:11714762-Radiation Hybrid Mapping,
pubmed-meshheading:11714762-Recombination, Genetic
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pubmed:year |
2001
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pubmed:articleTitle |
Cutting edge: A/WySnJ transitional B cells overexpress the chromosome 15 proapoptotic Blk gene and succumb to premature apoptosis.
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pubmed:affiliation |
Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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