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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2001-11-20
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pubmed:abstractText |
Interleukin (IL)-18 is a recently discovered cytokine that modulates both T helper type 1 (Th1) and Th2 responses. IL-18 is elevated during acute graft-versus-host disease (GVHD). We investigated the role of IL-18 in this disorder using a well characterized murine bone marrow transplantation (BMT) model (B6 --> B6D2F1). Surprisingly, blockade of IL-18 accelerated acute GVHD-related mortality. In contrast, administration of IL-18 reduced serum tumor necrosis factor (TNF)-alpha and lipopolysaccharide (LPS) levels, decreased intestinal histopathology, and resulted in significantly improved survival (75 vs. 15%, P < 0.001). Administration of IL-18 attenuated early donor T cell expansion and was associated with increased Fas expression and greater apoptosis of donor T cells. The administration of IL-18 no longer protected BMT recipients from GVHD when Fas deficient (lpr) mice were used as donors. IL-18 also lost its ability to protect against acute GVHD when interferon (IFN)-gamma knockout mice were used as donors. Together, these results demonstrate that IL-18 regulates acute GVHD by inducing enhanced Fas-mediated apoptosis of donor T cells early after BMT, and donor IFN-gamma is critical for this protective effect.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-10092771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-10534057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-10583597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-10779417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-10792004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-10820292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-10830730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-10886219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-10942393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-11101867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-11203186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-11244043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-11267498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-11336686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-11390444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-11418486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-1467511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-2147950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-2377601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-3316472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-7477296,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-7662991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-7833486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-7992370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-8245478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-8752918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-8963063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-9233615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-9376604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-9399965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-9498741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-9529155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-9558388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-9645383,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-9649564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-9802888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11714750-9854048
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
194
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1433-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11714750-Acute Disease,
pubmed-meshheading:11714750-Animals,
pubmed-meshheading:11714750-Antibodies, Monoclonal,
pubmed-meshheading:11714750-Antigens, CD95,
pubmed-meshheading:11714750-Apoptosis,
pubmed-meshheading:11714750-Bone Marrow Transplantation,
pubmed-meshheading:11714750-Female,
pubmed-meshheading:11714750-Graft vs Host Disease,
pubmed-meshheading:11714750-Interferon-gamma,
pubmed-meshheading:11714750-Interleukin-18,
pubmed-meshheading:11714750-Mice,
pubmed-meshheading:11714750-Mice, Inbred C57BL,
pubmed-meshheading:11714750-T-Lymphocytes
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pubmed:year |
2001
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pubmed:articleTitle |
Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosis.
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pubmed:affiliation |
Department of Internal Medicine and Pediatrics, University of Michigan Cancer Center, 1500 E. Medical Center Dr., Ann Arbor, MI 48109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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