pubmed-article:11714749 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C0004587 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C0031310 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C2263441 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C1548795 | lld:lifeskim |
pubmed-article:11714749 | lifeskim:mentions | umls-concept:C0291677 | lld:lifeskim |
pubmed-article:11714749 | pubmed:issue | 10 | lld:pubmed |
pubmed-article:11714749 | pubmed:dateCreated | 2001-11-20 | lld:pubmed |
pubmed-article:11714749 | pubmed:abstractText | Mycobacterium tuberculosis (MTB) inhibits phagosomal maturation to promote its survival inside macrophages. Control of MTB infection requires CD4 T cell responses and major histocompatibility complex (MHC) class II (MHC-II) processing of MTB antigens (Ags). To investigate phagosomal processing of MTB Ags, phagosomes containing heat-killed (HK) or live MTB were purified from interferon-gamma (IFN-gamma)-activated macrophages by differential centrifugation and Percoll density gradient subcellular fractionation. Flow organellometry and Western blot analysis showed that MTB phagosomes acquired lysosome-associated membrane protein-1 (LAMP-1), MHC-II, and H2-DM. T hybridoma cells were used to detect MTB Ag 85B(241-256)-I-A(b) complexes in isolated phagosomes and other subcellular fractions. These complexes appeared initially (within 20 min) in phagosomes and subsequently (>20 min) on the plasma membrane, but never within late endocytic compartments. Macrophages processed HK MTB more rapidly and efficiently than live MTB; phagosomes containing live MTB expressed fewer Ag 85B(241-256)-I-A(b) complexes than phagosomes containing HK MTB. This is the first study of bacterial Ag processing to directly show that peptide-MHC-II complexes are formed within phagosomes and not after export of bacterial Ags from phagosomes to endocytic Ag processing compartments. Live MTB can alter phagosome maturation and decrease MHC-II Ag processing, providing a mechanism for MTB to evade immune surveillance and enhance its survival within the host. | lld:pubmed |
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pubmed-article:11714749 | pubmed:language | eng | lld:pubmed |
pubmed-article:11714749 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11714749 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:11714749 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11714749 | pubmed:month | Nov | lld:pubmed |
pubmed-article:11714749 | pubmed:issn | 0022-1007 | lld:pubmed |
pubmed-article:11714749 | pubmed:author | pubmed-author:HardingC VCV | lld:pubmed |
pubmed-article:11714749 | pubmed:author | pubmed-author:BoopW CWC | lld:pubmed |
pubmed-article:11714749 | pubmed:author | pubmed-author:RamachandraLL | lld:pubmed |
pubmed-article:11714749 | pubmed:author | pubmed-author:NossEE | lld:pubmed |
pubmed-article:11714749 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11714749 | pubmed:day | 19 | lld:pubmed |
pubmed-article:11714749 | pubmed:volume | 194 | lld:pubmed |
pubmed-article:11714749 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11714749 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11714749 | pubmed:pagination | 1421-32 | lld:pubmed |
pubmed-article:11714749 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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