|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
23
|
|
pubmed:dateCreated |
2001-11-20
|
|
pubmed:abstractText |
N-3-Benzyloxycarbonylmethyl- and N-3-carboxymethyl-TBDMS-substituted nucleosides were synthesized and evaluated for activity against HIV replication. It was found that the N-3-carboxymethyl-TBDMS-substituted nucleosides were specific inhibitors of HIV-1 replication. They should be considered as members of a novel and original class of NNRTIs.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
3
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3085-8
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11714616-Drug Evaluation, Preclinical,
pubmed-meshheading:11714616-HIV Reverse Transcriptase,
pubmed-meshheading:11714616-HIV-1,
pubmed-meshheading:11714616-HIV-2,
pubmed-meshheading:11714616-Humans,
pubmed-meshheading:11714616-Nucleosides,
pubmed-meshheading:11714616-Organosilicon Compounds,
pubmed-meshheading:11714616-Reverse Transcriptase Inhibitors,
pubmed-meshheading:11714616-Structure-Activity Relationship,
pubmed-meshheading:11714616-Tumor Cells, Cultured
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Identification of a novel family of nucleosides that specifically inhibit HIV-1 reverse transcriptase.
|
|
pubmed:affiliation |
Instituto de Química Médica (C.S.I.C.), Juan de la Cierva 3, 28006-Madrid, Spain.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
