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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2001-11-20
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|
pubmed:abstractText |
The efficacy of piperacillin/tazobactam at 100/12.5 mg/kg every 8 h (35 patients) was compared to cefotaxime plus metronidazole at 50/7.5 mg/kg every 8 h (35 patients) in 70 children with intra-abdominal infections requiring surgery. Diagnoses were gangrenous or perforated appendicitis (n =56), peritonitis (n =12), and abscess (n =2). Clinical cure was observed in 35 of 35 evaluable patients treated with piperacilin/tazobactam and in 34 of 34 evaluable patients treated with cefotaxime plus metronidazole. Presumed bacteriological eradication was noted in 29 of 30 evaluable patients in the piperacillin/tazobactam group and in 31 of 31 evaluable patients in the cefotaxime plus metronidazole group. In this study, piperacillin/tazobactam was as effective as cefotaxime plus metronidazole for treating children with intra-abdominal infections requiring surgery.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0934-9723
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
643-6
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|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11714046-Abdominal Abscess,
pubmed-meshheading:11714046-Adolescent,
pubmed-meshheading:11714046-Appendicitis,
pubmed-meshheading:11714046-Bacterial Infections,
pubmed-meshheading:11714046-Cefotaxime,
pubmed-meshheading:11714046-Child,
pubmed-meshheading:11714046-Child, Preschool,
pubmed-meshheading:11714046-Drug Combinations,
pubmed-meshheading:11714046-Drug Therapy, Combination,
pubmed-meshheading:11714046-Female,
pubmed-meshheading:11714046-Follow-Up Studies,
pubmed-meshheading:11714046-Humans,
pubmed-meshheading:11714046-Intestinal Perforation,
pubmed-meshheading:11714046-Male,
pubmed-meshheading:11714046-Metronidazole,
pubmed-meshheading:11714046-Microbial Sensitivity Tests,
pubmed-meshheading:11714046-Penicillanic Acid,
pubmed-meshheading:11714046-Peritonitis,
pubmed-meshheading:11714046-Piperacillin,
pubmed-meshheading:11714046-Prospective Studies,
pubmed-meshheading:11714046-Treatment Outcome
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|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Piperacillin/Tazobactam versus cefotaxime plus metronidazole for treatment of children with intra-abdominal infections requiring surgery.
|
|
pubmed:affiliation |
University of Athens Second Department of Pediatrics, P. & A. Kyriakou Children's Hospital, Athens, Greece.
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|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|
