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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6861
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pubmed:dateCreated |
2001-11-19
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pubmed:abstractText |
The plant hormone auxin is central in many aspects of plant development. Previous studies have implicated the ubiquitin-ligase SCF(TIR1) and the AUX/IAA proteins in auxin response. Dominant mutations in several AUX/IAA genes confer pleiotropic auxin-related phenotypes, whereas recessive mutations affecting the function of SCF(TIR1) decrease auxin response. Here we show that SCF(TIR1) is required for AUX/IAA degradation. We demonstrate that SCF(TIR1) interacts with AXR2/IAA7 and AXR3/IAA17, and that domain II of these proteins is necessary and sufficient for this interaction. Further, auxin stimulates binding of SCF(TIR1) to the AUX/IAA proteins, and their degradation. Because domain II is conserved in nearly all AUX/IAA proteins in Arabidopsis, we propose that auxin promotes the degradation of this large family of transcriptional regulators, leading to diverse downstream effects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/AXR1 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/AXR3 protein, Arabidopsis,
http://linkedlifedata.com/resource/pubmed/chemical/Arabidopsis Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronidase,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Indoleacetic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SKP Cullin F-Box Protein Ligases,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquitin,
http://linkedlifedata.com/resource/pubmed/chemical/indoleacetic acid
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
414
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
271-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11713520-Amino Acid Motifs,
pubmed-meshheading:11713520-Arabidopsis,
pubmed-meshheading:11713520-Arabidopsis Proteins,
pubmed-meshheading:11713520-Gene Expression Regulation, Plant,
pubmed-meshheading:11713520-Glucuronidase,
pubmed-meshheading:11713520-Growth Substances,
pubmed-meshheading:11713520-Indoleacetic Acids,
pubmed-meshheading:11713520-Mutation,
pubmed-meshheading:11713520-Nuclear Proteins,
pubmed-meshheading:11713520-Peptide Synthases,
pubmed-meshheading:11713520-Plant Proteins,
pubmed-meshheading:11713520-Plants, Genetically Modified,
pubmed-meshheading:11713520-Protein Binding,
pubmed-meshheading:11713520-Recombinant Fusion Proteins,
pubmed-meshheading:11713520-SKP Cullin F-Box Protein Ligases,
pubmed-meshheading:11713520-Ubiquitin
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pubmed:year |
2001
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pubmed:articleTitle |
Auxin regulates SCF(TIR1)-dependent degradation of AUX/IAA proteins.
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pubmed:affiliation |
The Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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