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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0017262,
umls-concept:C0017710,
umls-concept:C0019682,
umls-concept:C0021760,
umls-concept:C0023978,
umls-concept:C0085862,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0441712,
umls-concept:C1299583,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C2911684
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pubmed:issue |
10
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pubmed:dateCreated |
2001-11-19
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pubmed:abstractText |
Glucocorticoids (GC) such as dexamethasone (Dex) can directly upregulate human immunodeficiency virus type-1 (HIV-1) replication in acutely infected cells and potentiate HIV expression from chronically infected promonocytic U1 cells stimulated with tumor necrosis factor-alpha (TNF-alpha). We have here investigated the potential effect of Dex in U1 cells stimulated with interleukin-6 (IL-6), a cytokine inducing virus expression by acting mostly at a post-transcriptional level on the virus life cycle.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/CCL2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chloramphenicol O-Acetyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Dexamethasone,
http://linkedlifedata.com/resource/pubmed/chemical/Glucocorticoids,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glucocorticoid,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/dexamethasone 21-methanesulfonate
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1076-1551
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
668-78
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11713366-Autoantigens,
pubmed-meshheading:11713366-Blotting, Northern,
pubmed-meshheading:11713366-Blotting, Western,
pubmed-meshheading:11713366-Chemokine CCL2,
pubmed-meshheading:11713366-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:11713366-Dexamethasone,
pubmed-meshheading:11713366-Drug Synergism,
pubmed-meshheading:11713366-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:11713366-Glucocorticoids,
pubmed-meshheading:11713366-HIV Long Terminal Repeat,
pubmed-meshheading:11713366-HIV-1,
pubmed-meshheading:11713366-Humans,
pubmed-meshheading:11713366-Interleukin-6,
pubmed-meshheading:11713366-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:11713366-Monocytes,
pubmed-meshheading:11713366-RNA, Viral,
pubmed-meshheading:11713366-Receptors, Glucocorticoid,
pubmed-meshheading:11713366-Signal Transduction,
pubmed-meshheading:11713366-Transcription Factor AP-1,
pubmed-meshheading:11713366-Virus Activation,
pubmed-meshheading:11713366-Virus Replication
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pubmed:year |
2001
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pubmed:articleTitle |
Interleukin-6 and glucocorticoids synergistically induce human immunodeficiency virus type-1 expression in chronically infected U1 cells by a long terminal repeat independent post-transcriptional mechanism.
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pubmed:affiliation |
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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