Linked Life Data

11712403

Source:http://linkedlifedata.com/resource/pubmed/id/11712403

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-11-19
pubmed:abstractText
PPAR gamma is a major determinants of adipocyte differentiation and its activation by ligands including thiazolidinedione(TZDs) and the endogenous ligands induces transcription of the genes involving glucose and lipid metabolism. By the experiments using animal models with obesity-related phenotypes and PPAR gamma knockout mouse and the results of genetics study regarding on the mutations and SNPs in human, it is postulated that the PPAR gamma activation determines and modifies insulin sensitivity by the relationship between the degree of the activation and potency of ligands(agonists/antagonists). The modulation of the PPAR gamma activation by synthetic agonist/antagonists will be beneficial in the prevention and treatment of type 2 diabetes and obesity-related phenotypes.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0047-1852
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2173-8
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
[A role of the PPAR gamma activation in insulin resistance].
pubmed:affiliation
Department of Atherosclerosis and Diabetes, National Cardiovascular Center.
pubmed:publicationType
Journal Article, English Abstract