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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
2001-11-16
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pubmed:abstractText |
There is substantial evidence implicating excitotoxicity and oxidative damage in the pathogenesis of Huntington's disease (HD). We therefore examined whether the antioxidants 2-sulpho-tert-phenyibutyinitrone (S-PBN) and alpha-lipoic acid could exert neuroprotective effects in transgenic mouse models of HD. S-PBN showed no effects on either weight loss or survival in the R6/2 transgenic HD mice. alpha-Lipoic acid produced significant increases in survival in both R6/2 and N171-82Q transgenic mouse models of HD. These findings suggest that alpha-lipoic acid might have beneficial effects in HD patients.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0959-4965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3371-3
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11711888-Animals,
pubmed-meshheading:11711888-Antioxidants,
pubmed-meshheading:11711888-Benzenesulfonates,
pubmed-meshheading:11711888-Body Weight,
pubmed-meshheading:11711888-Brain,
pubmed-meshheading:11711888-Disease Models, Animal,
pubmed-meshheading:11711888-Food, Formulated,
pubmed-meshheading:11711888-Huntington Disease,
pubmed-meshheading:11711888-Male,
pubmed-meshheading:11711888-Mice,
pubmed-meshheading:11711888-Mice, Transgenic,
pubmed-meshheading:11711888-Neuroprotective Agents,
pubmed-meshheading:11711888-Oxidative Stress,
pubmed-meshheading:11711888-Survival,
pubmed-meshheading:11711888-Thioctic Acid,
pubmed-meshheading:11711888-Treatment Outcome
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pubmed:year |
2001
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pubmed:articleTitle |
Lipoic acid improves survival in transgenic mouse models of Huntington's disease.
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pubmed:affiliation |
Neurochemistry Laboratory, Neurology Service, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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