Linked Life Data

11711504

Source:http://linkedlifedata.com/resource/pubmed/id/11711504

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-11-16
pubmed:abstractText
We determined cardiovascular and neurohormonal responses to intracerebroventricular administration of human cocaine- and amphetamine-regulated transcript (CART) peptide 55-102 in conscious rabbits. Intracerebroventricular injection of CART 55-102 elicited dose-related increases in mean arterial pressure and renal sympathetic nerve activity. Peak values of mean arterial pressure and renal sympathetic nerve activity induced by intracerebroventricular injection of 1 nmol of CART 55-102 (+5.0+/-2.6 mm Hg and +72.5+/-20.8%) were obtained 40 and 60 minutes after injection, respectively. Plasma epinephrine and glucose concentrations significantly increased 30 and 60 minutes after intracerebroventricular injection of CART 55-102 (control versus 60 minutes for epinephrine, 77.0+/-62.4 versus 1067.5+/-329.3 pg/mL, P<0.01; for glucose, 6.25+/-0.33 versus 11.57+/-0.93 mmol/L, P<0.01). Plasma norepinephrine concentrations also significantly increased at 30 minutes. Plasma insulin, vasopressin, and cortisol concentrations increased at 60 minutes but did not attain significant values. However, pretreatment with intravenous injection of pentolinium (5 mg/kg), a ganglion-blocking agent, eliminated these cardiovascular and neurohormonal responses. In contrast, intravenous injection of the same dosage of CART 55-102 (1 nmol) as that used in the intracerebroventricular experiment failed to cause any cardiovascular and renal sympathetic nerve responses. These results suggest that intracerebroventricular human CART 55-102 acts in the central nervous system and activates sympathoadrenal outflow, which results in increases in arterial pressure and plasma glucose levels in conscious rabbits.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1524-4563
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1096-100
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11711504-Animals, pubmed-meshheading:11711504-Blood Glucose, pubmed-meshheading:11711504-Blood Pressure, pubmed-meshheading:11711504-Consciousness, pubmed-meshheading:11711504-Dose-Response Relationship, Drug, pubmed-meshheading:11711504-Epinephrine, pubmed-meshheading:11711504-Ganglionic Blockers, pubmed-meshheading:11711504-Heart Rate, pubmed-meshheading:11711504-Humans, pubmed-meshheading:11711504-Injections, Intravenous, pubmed-meshheading:11711504-Injections, Intraventricular, pubmed-meshheading:11711504-Kidney, pubmed-meshheading:11711504-Male, pubmed-meshheading:11711504-Nerve Tissue Proteins, pubmed-meshheading:11711504-Neuropeptides, pubmed-meshheading:11711504-Norepinephrine, pubmed-meshheading:11711504-Pentolinium Tartrate, pubmed-meshheading:11711504-Peptide Fragments, pubmed-meshheading:11711504-Rabbits, pubmed-meshheading:11711504-Sympathetic Nervous System
pubmed:year
2001
pubmed:articleTitle
Central human cocaine- and amphetamine-regulated transcript peptide 55-102 increases arterial pressure in conscious rabbits.
pubmed:affiliation
Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. matsumk@intmed2.med.kyushu-u.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't